Managing acute respiratory failure in patients with cancer, part 2 Journal Article

Author: Pastores, S. M.
Article Title: Managing acute respiratory failure in patients with cancer, part 2
Abstract: The management of acute respiratory failure in patients with cancer is generally supportive, but specific therapies vary according to the underlying cause. The treatment of Aspergillus pneumonia often includes amphotericin B or liposomal amphotericin B; alternatives include caspofungin and voriconazole. Intravenous unfractionated heparin and subcutaneous low molecular weight heparin are both safe and effective for treating pulmonary embolism in patients with cancer. For patients with acute respiratory distress syndrome, the use of mechanical ventilation with lower tidal volumes has been associated with improved outcome. Treatment of diffuse alveolar hemorrhage includes platelet transfusions, correction of any coagulopathy and, in severe cases, high-dose corticosteroids. Chemotherapy with hydroxyurea and leukapheresis is the primary intervention for respiratory failure related to hyperleukocytic leukemias. The early use of noninvasive positive pressure ventilation can obviate the need for endotracheal intubation and can improve survival in select patients.
Keywords: survival; treatment outcome; leukemia; hydroxyurea; review; cancer patient; drug megadose; disease association; bleeding; pneumonia; lung embolism; disease severity; warfarin; heparin; corticosteroid; blood clotting disorder; caspofungin; voriconazole; aspergillus; thrombocyte transfusion; low molecular weight heparin; artificial ventilation; respiratory distress syndrome; lung hemorrhage; leukapheresis; acute respiratory failure; acute respiratory distress syndrome; amphotericin b lipid complex; tidal volume; endotracheal intubation; amphotericin b; human; low molecular weight heparin versus standard heparin; prognosis and outcome; treatment in the setting of pneumonia, iatrogenic lung injury, and venous thromboembolism; intermittent positive pressure ventilation
Journal Title: Journal of Respiratory Diseases
Volume: 24
Issue: 12
ISSN: 0194-259X
Publisher: Cliggott  
Date Published: 2003-12-01
Start Page: 543
End Page: 550
Language: English
PROVIDER: scopus
Notes: Export Date: 25 September 2014 -- Source: Scopus