Acute respiratory failure in the patient with cancer: Diagnostic and management strategies Journal Article
| Authors: | Pastores, S. M.; Voigt, L. P. |
| Article Title: | Acute respiratory failure in the patient with cancer: Diagnostic and management strategies |
| Abstract: | Acute respiratory failure (ARF) remains the major reason for admission to the intensive care unit (ICU) in patients with cancer and is often associated with high mortality, especially in those who require mechanical ventilation. The diagnosis and management of ARF in patients who have cancer pose unique challenges to the intensivist. This article reviews the most common causes of ARF in patients with cancer and discusses recent advances in the diagnostic and management approaches of these disorders. Timely diagnosis and treatment of reversible causes of respiratory failure, including earlier use of noninvasive ventilation and judicious ventilator and fluid management in patients with acute lung injury, are essential to achieve an optimal outcome. Close collaboration between oncologists and intensivists helps ensure that clear goals, including direction of treatment and quality of life, are established for every patient with cancer who requires mechanical ventilation for ARF. © 2010. |
| Keywords: | treatment outcome; antibiotic agent; clinical trial; drug tolerability; mortality; review; angiogenesis inhibitor; drug efficacy; drug safety; drug withdrawal; nonhuman; treatment duration; cancer radiotherapy; drug megadose; antineoplastic agent; sensitivity and specificity; neoplasms; unindexed drug; oxygen; immunoglobulin; pneumocystis pneumonia; practice guideline; radiation injury; pneumonia; intensive care; intensive care units; antiinfective agent; antibiotic resistance; disease severity; hematologic malignancy; diagnosis; comorbidity; blood transfusion; heparin; bleomycin; neuroleptic agent; outcome; malignant neoplastic disease; cytokine production; bronchoscopy; methylprednisolone; immunomodulating agent; ketoconazole; platinum complex; corticosteroid; mitomycin; paraneoplastic syndrome; drug treatment failure; prostaglandin e; cotrimoxazole; lung biopsy; management; atovaquone; pentamidine; ribavirin; cytomegalovirus infection; mycosis; critical care; hypersensitivity reaction; lung infiltrate; virus pneumonia; acute disease; narcotic agent; bronchospasm; respiratory insufficiency; respiratory failure; venous thromboembolism; anticoagulant agent; critical illness; interstitial pneumonia; critically ill patient; lung hemorrhage; nitric oxide; sedative agent; acute respiratory failure; bacterial pneumonia; lung injury; patient admission; mechanical ventilation; 2 oxo 4 thiazolidinecarboxylic acid; lisofylline; prostacyclin; selective androgen receptor modulator; surfactant; capillary leak syndrome; organizing pneumonia |
| Journal Title: | Critical Care Clinics |
| Volume: | 26 |
| Issue: | 1 |
| ISSN: | 0749-0704 |
| Publisher: | W.B. Saunders Co. |
| Date Published: | 2010-01-01 |
| Start Page: | 21 |
| End Page: | 40 |
| Language: | English |
| DOI: | 10.1016/j.ccc.2009.10.001 |
| PUBMED: | 19944274 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 3" - "Export Date: 20 April 2011" - "CODEN: CCCLE" - "Source: Scopus" |
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