Autocrine transforming growth factor-β1 promotes in vivo Th17 cell differentiation Journal Article

   


Authors: Gutcher, I.; Donkor, M.; Ma, Q.; Rudensky, A.; Flavell, R.; Li, M.
Article Title: Autocrine transforming growth factor-β1 promotes in vivo Th17 cell differentiation
Abstract: TGF-β1 is a regulatory cytokine that has an important role in controlling T cell differentiation. T cell-produced TGF-β1 acts on T cells to promote Th17 cell differentiation and the development of experimental autoimmune encephalomyelitis (EAE). However, the exact TGF-β1-producing T cell subset required for Th17 cell generation and its cellular mechanism of action remain unknown. Here we showed that deletion of the Tgfb1 gene from activated T cells and Treg cells, but not Treg cells alone, abrogated Th17 cell differentiation, resulting in almost complete protection from EAE. Furthermore, differentiation of T cells both in vitro and in vivo demonstrated that TGF-β1 was highly expressed by Th17 cells and acted in a predominantly autocrine manner to maintain Th17 cells in vivo. These findings reveal an essential role for activated T cell-produced TGF-β1 in promoting the differentiation of Th17 cells and controlling inflammatory diseases. © 2011 Elsevier Inc.
Keywords: controlled study; gene deletion; nonhuman; animal cell; mouse; animal experiment; animal model; lymphocyte differentiation; regulatory t lymphocyte; transforming growth factor beta1; autocrine effect; th17 cell; t lymphocyte activation; allergic encephalomyelitis; inflammatory disease
Journal Title: Immunity
Volume: 34
Issue: 3
ISSN: 1074-7613
Publisher: Cell Press  
Date Published: 2011-03-25
Start Page: 396
End Page: 408
Language: English
DOI: 10.1016/j.immuni.2011.03.005
PROVIDER: scopus
PUBMED: 21435587
PMCID: PMC3690311
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-79952771167&partnerID=40&md5=e198eb22bdcf594ef542957970e07b54
Notes: --- - "Cited By (since 1996): 1" - "Export Date: 23 June 2011" - "CODEN: IUNIE" - "Source: Scopus"
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MSK Authors
  1. Alexander Rudensky
    156 Rudensky
  2. Ming Li
    111 Li
  3. Moses K Donkor
    3 Donkor
  4. Ilona Gutcher
    2 Gutcher
  5. Qian Ma
    5 Ma
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