Contextual regulation of inflammation: A duet by transforming growth factor-β and interleukin-10 Journal Article
| Authors: | Li, M. O.; Flavell, R. A. |
| Article Title: | Contextual regulation of inflammation: A duet by transforming growth factor-β and interleukin-10 |
| Abstract: | Transforming growth factor-β (TGF-β) and interleukin-10 (IL-10) are regulatory cytokines with pleiotropic roles in the immune system. The prominent function of TGF-β is to maintain T cell tolerance to self or innocuous environmental antigens via its direct effects on the differentiation and homeostasis of effector and regulatory T cells. A critical route for the regulation of T cells by TGF-β is via activation of a T cell-produced latent form of TGF-β1 by dendritic cell-expressed avβ8 integrin. IL-10 operates primarily as a feedback inhibitor of exuberant T cell responses to microbial antigens. T cells are also the principal producers of IL-10, the expression of which is regulated by IL-27, IL-6, and TGF-β. The collective activity of TGF-β and IL-10 ensures a controlled inflammatory response specifically targeting pathogens without evoking excessive immunopathology to self-tissues. © 2008 Elsevier Inc. All rights reserved. |
| Keywords: | signal transduction; protein expression; unclassified drug; review; nonhuman; protein function; cd8 antigen; transcription factor foxp3; cd8+ t lymphocyte; animals; mice; stat3 protein; unindexed drug; immune system; infection; dendritic cell; transforming growth factor beta; interleukin 10; inflammation; inflammation mediators; experimental mouse; t lymphocyte receptor; cytokine; immunological tolerance; regulatory t lymphocyte; th2 cell; cellular immunity; immune response; regulatory mechanism; diabetes mellitus; cd4+ t lymphocyte; interleukin 6; transforming growth factor beta1; colitis; cytokine production; effector cell; innate immunity; protein kinase tyk2; tumor model; t-lymphocyte subsets; cd4 antigen; transcription factor t bet; th1 cell; retinol; host resistance; retinoic acid; trypanosoma cruzi; integrin; t lymphocyte activation; myeloid differentiation factor 88; toll like receptor; immunopathology; epstein barr virus; interleukin 17f; interleukin 22; pleiotropy; immunopathogenesis; feedback, biochemical; interleukin-10; toxoplasmosis; transforming growth factor beta3; transforming growth factor beta receptor 2; neutralizing antibody; lymphocytic choriomeningitis virus; interleukin 23; transforming growth factor beta2; intestine lymphatic tissue; trypanosomiasis; alphavbeta8 integrin; bacterial antigen; interleukin 10 receptor; interleukin 17a; interleukin 27; allergic encephalitis; leishmania major; lymphocyte homing; toxoplasma gondii; virus meningitis |
| Journal Title: | Immunity |
| Volume: | 28 |
| Issue: | 4 |
| ISSN: | 1074-7613 |
| Publisher: | Cell Press |
| Date Published: | 2008-04-11 |
| Start Page: | 468 |
| End Page: | 476 |
| Language: | English |
| DOI: | 10.1016/j.immuni.2008.03.003 |
| PUBMED: | 18400189 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 108" - "Export Date: 17 November 2011" - "CODEN: IUNIE" - "Source: Scopus" |
