TGF-β control of adaptive immune tolerance: A break from Treg cells Journal Article
| Authors: | Liu, M.; Li, S.; Li, M. O. |
| Article Title: | TGF-β control of adaptive immune tolerance: A break from Treg cells |
| Abstract: | The vertebrate adaptive immune system has well defined functions in maintaining tolerance to self-tissues. Suppression of autoreactive T cells is dependent on the regulatory cytokine transforming growth factor-β (TGF-β) and regulatory T (Treg) cells, a distinct T cell lineage specified by the transcription factor Foxp3. Although TGF-β promotes thymic Treg (tTreg) cell development by repressing T cell clonal deletion and peripheral Treg cell differentiation by inducing Foxp3 expression, a recent study shows that TGF-β suppresses autoreactive T cells independent of Foxp3+ Treg cells. These findings imply that as an ancestral growth factor family member, TGF-β may have been co-opted as a T cell-intrinsic mechanism of self-tolerance control to assist the evolutionary transition of vertebrate adaptive immunity. Later, perhaps in placental mammals upon their acquisition of a TGF-β regulatory element in the Foxp3 locus, the TGF-β pathway is further engaged to induce peripheral Treg cell differentiation and expand the scope of T cell tolerance control to innocuous foreign antigens. © 2018 WILEY Periodicals, Inc. |
| Keywords: | evolution; immune tolerance; autoimmunity; adaptive immunity; foxp3; tgf-β; treg |
| Journal Title: | BioEssays |
| Volume: | 40 |
| Issue: | 11 |
| ISSN: | 0265-9247 |
| Publisher: | John Wiley & Sons |
| Date Published: | 2018-11-01 |
| Start Page: | 1800063 |
| Language: | English |
| DOI: | 10.1002/bies.201800063 |
| PUBMED: | 30159904 |
| PROVIDER: | scopus |
| PMCID: | PMC6300063 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 1 November 2018 -- Source: Scopus |
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