Regulation of the immune response by TGF-β: From conception to autoimmunity and infection Journal Article
| Authors: | Sanjabi, S.; Oh, S. A.; Li, M. O. |
| Article Title: | Regulation of the immune response by TGF-β: From conception to autoimmunity and infection |
| Abstract: | Transforming growth factor β (TGF-β) is a pleiotropic cytokine involved in both suppressive and inflammatory immune responses. After 30 years of intense study, we have only begun to elucidate how TGF-β alters immunity under various conditions. Under steady-state conditions, TGF-β regulates thymic T-cell selection and maintains homeostasis of the naïve T-cell pool. TGF-β inhibits cytotoxic T lymphocyte (CTL), Th1-, and Th2-cell differentiation while promoting peripheral (p)Treg-, Th17-, Th9-, and Tfh-cell generation, and T-cell tissue resi-dence in response to immune challenges. Similarly, TGF-β controls the proliferation, survival, activation, and differentiation of B cells, as well as the development and functions of innate cells, including natural killer (NK) cells, macrophages, dendritic cells, and granulocytes. Collectively, TGF-β plays a pivotal role in maintaining peripheral tolerance against self-and innocuous antigens, such as food, commensal bacteria, and fetal alloantigens, and in controlling immune responses to pathogens. © 2017 Cold Spring Harbor Laboratory Press; all rights reserved. |
| Journal Title: | Cold Spring Harbor Perspectives in Biology |
| Volume: | 9 |
| Issue: | 6 |
| ISSN: | 1943-0264 |
| Publisher: | Cold Spring Harbor Laboratory Press |
| Date Published: | 2017-06-01 |
| Start Page: | a022236 |
| Language: | English |
| DOI: | 10.1101/cshperspect.a022236 |
| PROVIDER: | scopus |
| PUBMED: | 28108486 |
| PMCID: | PMC5453394 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 3 July 2017 -- Source: Scopus |
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