TGF-β: A Master of All T Cell Trades Journal Article
| Authors: | Li, M. O.; Flavell, R. A. |
| Article Title: | TGF-β: A Master of All T Cell Trades |
| Abstract: | A functional adaptive immune system depends on a diverse and self-tolerant population of T lymphocytes that are generated in the thymus and maintained in the peripheral lymphoid organs. Recent studies have defined the cytokine transforming growth factor-β (TGF-β) as a critical regulator of thymic T cell development as well as a crucial player in peripheral T cell homeostasis, tolerance to self antigens, and T cell differentiation during the immune response. The unique mechanism of TGF-β activation and the plasticity of TGF-β signaling create a stage for TGF-β to integrate signals from multiple cell types and environmental cues to regulate T cells. © 2008 Elsevier Inc. All rights reserved. |
| Keywords: | signal transduction; review; cd8+ t lymphocyte; t lymphocyte; t-lymphocytes; animals; mice; cell maturation; transforming growth factor beta; cell differentiation; cell type; lymphocyte differentiation; immunological tolerance; regulatory t lymphocyte; cellular immunity; thymus; thymus gland; transforming growth factor beta1; adaptive immunity; homeostasis; integrin; lymphoid organ; helper cell; natural killer t cell; lymphocyte subpopulation; alphavbeta6 integrin; integrin alpha5beta8 |
| Journal Title: | Cell |
| Volume: | 134 |
| Issue: | 3 |
| ISSN: | 0092-8674 |
| Publisher: | Cell Press |
| Date Published: | 2008-08-08 |
| Start Page: | 392 |
| End Page: | 404 |
| Language: | English |
| DOI: | 10.1016/j.cell.2008.07.025 |
| PUBMED: | 18692464 |
| PROVIDER: | scopus |
| PMCID: | PMC3677783 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 138" - "Export Date: 17 November 2011" - "CODEN: CELLB" - "Source: Scopus" |
