Foxp3+ regulatory T cells promote T helper 17 cell development in vivo through regulation of interleukin-2 Journal Article

  


Authors: Chen, Y.; Haines, C.; Gutcher, I.; Hochweller, K.; Blumenschein, W.; McClanahan, T.; Hämmerling, G.; Li, M.; Cua, D.; McGeachy, M.
Article Title: Foxp3+ regulatory T cells promote T helper 17 cell development in vivo through regulation of interleukin-2
Abstract: T helper 17 (Th17) cell development is driven by cytokines including transforming growth factor-β (TGF-β), interleukin-6 (IL-6), IL-1, and IL-23. Regulatory T (Treg) cells can provide the TGF-β in vitro, but their role in vivo remains unclear, particularly because Treg cells inhibit inflammation in many models of Th17 cell-associated autoimmunity. We used mice expressing Diphtheria toxin receptor under control of the Foxp3 promoter to deplete Foxp3+ Treg cells in adult mice during in vivo Th17 cell priming. Treg cell depletion resulted in a reduced frequency of antigen-specific IL-17 producers in draining lymph nodes and blood, correlating with reduced inflammatory skin responses. In contrast, Treg cells did not promote IL-17 secretion after initial activation stages. Treg cell production of TGF-β was not required for Th17 cell promotion, and neither was suppression of Th1 cell-associated cytokines. Rather, regulation of IL-2 availability and resultant signaling through CD25 by Treg cells was found to play an important role. © 2011 Elsevier Inc.
Keywords: controlled study; promoter region; nonhuman; transcription factor foxp3; animal cell; mouse; interleukin 2; transforming growth factor beta; animal experiment; regulatory t lymphocyte; cytokine production; interleukin 17; th17 cell; th1 cell; diphtheria toxin; interleukin 2 receptor alpha
Journal Title: Immunity
Volume: 34
Issue: 3
ISSN: 1074-7613
Publisher: Cell Press  
Date Published: 2011-03-25
Start Page: 409
End Page: 421
Language: English
DOI: 10.1016/j.immuni.2011.02.011
PROVIDER: scopus
PUBMED: 21435588
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-79952761637&partnerID=40&md5=3f297213f89b7a0f8d71a5a8124080c6
Notes: --- - "Cited By (since 1996): 2" - "Export Date: 23 June 2011" - "CODEN: IUNIE" - "Source: Scopus"
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MSK Authors
  1. Ming Li
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  2. Ilona Gutcher
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