T cell- but not tumor cell-produced TGF-β1 promotes the development of spontaneous mammary cancer Journal Article
| Authors: | Sarkar, A.; Donkor, M. K.; Li, M. O. |
| Article Title: | T cell- but not tumor cell-produced TGF-β1 promotes the development of spontaneous mammary cancer |
| Abstract: | During their development, tumors acquire multiple capabilities that enable them to proliferate, disseminate and evade immunosurveillance. A putative mechanism is through the production of the cytokine TGF-β1. We showed in our recent studies that T cell-produced TGF-β1 inhibits antitumor T cell responses to foster tumor growth raising the question of the precise function of TGF-β1 produced by tumor cells in tumor development. Here, using a transgenic model of mammary cancer, we report that deletion of TGF-β1 from tumor cells did not protect mice from tumor development. However, ablation of TGF-β1 from T cells significantly inhibited mammary tumor growth. Additionally, absence of TGF-β1 in T cells prevented tumors from advancing to higher pathological grades and further suppressed secondary tumor development in the lungs. These findings reveal T cells but not tumor cells as a critical source of TGF-β1 that promotes tumor development. |
| Keywords: | genetics; t lymphocyte; t-lymphocytes; mouse; animal; metabolism; mouse mutant; animals; mice; mice, knockout; transforming growth factor beta; pathology; mice, inbred c57bl; c57bl mouse; experimental neoplasm; mammary neoplasms, experimental; mammary neoplasms, animal |
| Journal Title: | Oncotarget |
| Volume: | 2 |
| Issue: | 12 |
| ISSN: | 1949-2553 |
| Publisher: | Impact Journals |
| Date Published: | 2011-12-01 |
| Start Page: | 1339 |
| End Page: | 1351 |
| Language: | English |
| PUBMED: | 22248703 |
| PROVIDER: | scopus |
| PMCID: | PMC3282091 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 1 August 2012" - "Source: Scopus" |
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