T cell surveillance of oncogene-induced prostate cancer is impeded by T cell-derived TGF-β1 cytokine Journal Article

   

Authors:	Donkor, M. K.; Sarkar, A.; Savage, P. A.; Franklin, R. A.; Johnson, L. K.; Jungbluth, A. A.; Allison, J. P.; Li, M. O.
Article Title:	T cell surveillance of oncogene-induced prostate cancer is impeded by T cell-derived TGF-β1 cytokine
Abstract:	Tolerance induction in T cells takes place in most tumors and is thought to account for tumor evasion from immune eradication. Production of the cytokine TGF-β is implicated in immunosuppression, but the cellular mechanism by which TGF-β induces T cell dysfunction remains unclear. With a transgenic model of prostate cancer, we showed that tumor development was not suppressed by the adaptive immune system, which was associated with heightened TGF-β signaling in T cells from the tumor-draining lymph nodes. Blockade of TGF-β signaling in T cells enhanced tumor antigen-specific T cell responses and inhibited tumor development. Surprisingly, T cell- but not Treg cell-specific ablation of TGF-β1 was sufficient to augment T cell cytotoxic activity and blocked tumor growth and metastases. These findings reveal that T cell production of TGF-β1 is an essential requirement for tumors to evade immunosurveillance independent of TGF-β produced by tumors. © 2011 Elsevier Inc.
Journal Title:	Immunity
Volume:	35
Issue:	1
ISSN:	1074-7613
Publisher:	Cell Press
Date Published:	2011-07-22
Start Page:	123
End Page:	134
Language:	English
DOI:	10.1016/j.immuni.2011.04.019
PROVIDER:	scopus
PUBMED:	21757379
PMCID:	PMC3430371
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-79960451984&partnerID=40&md5=f45ffe9ef162c6c2931b690ba1ec0084
Notes:	--- - "Export Date: 17 August 2011" - "CODEN: IUNIE" - "Source: Scopus"

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