Structure of two intramolecular G-quadruplexes formed by natural human telomere sequences in K+ solution Journal Article
| Authors: | Phan, A. T.; Kuryavyi, V.; Luu, K. N.; Patel, D. J. |
| Article Title: | Structure of two intramolecular G-quadruplexes formed by natural human telomere sequences in K+ solution |
| Abstract: | Intramolecular G-quadruplexes formed by human telomere sequences are attractive anticancer targets. Recently, four-repeat human telomere sequences have been shown to form two different intramolecular (3+1) G-quadruplexes in K+ solution (Form 1 and Form 2). Here we report on the solution structures of both Form 1 and Form 2 adopted by natural human telomere sequences. Both structures contain the (3+1) G-tetrad core with one double-chain-reversal and two edgewise loops, but differ in the successive order of loop arrangements within the G-quadruplex scaffold. Our results provide the structural details at the two ends of the G-tetrad core in the context of natural sequences and information on different loop conformations. This structural information might be important for our understanding of telomere G-quadruplex structures and for anticancer drug design targeted to such scaffolds. © 2007 The Author(s). |
| Keywords: | cancer chemotherapy; controlled study; drug targeting; antineoplastic agent; telomere; complex formation; drug design; dna; guanine; 5' untranslated region; nuclear magnetic resonance spectroscopy; base sequence; dna sequence; models, molecular; solutions; 3' untranslated region; structure analysis; repetitive sequences, nucleic acid; g-quadruplexes; potassium; nuclear magnetic resonance, biomolecular; nucleic acid base substitution; potassium chloride; nuclear overhauser effect; cations |
| Journal Title: | Nucleic Acids Research |
| Volume: | 35 |
| Issue: | 19 |
| ISSN: | 0305-1048 |
| Publisher: | Oxford University Press |
| Date Published: | 2007-10-01 |
| Start Page: | 6517 |
| End Page: | 6525 |
| Language: | English |
| DOI: | 10.1093/nar/gkm706 |
| PUBMED: | 17895279 |
| PROVIDER: | scopus |
| PMCID: | PMC2095816 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 95" - "Export Date: 17 November 2011" - "CODEN: NARHA" - "Source: Scopus" |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work