Structure of the human telomere in K+ solution: An intramolecular (3 + 1) G-quadruplex scaffold Journal Article
| Authors: | Luu, K. N.; Phan, A. T.; Kuryavyi, V.; Lacroix, L.; Patel, D. J. |
| Article Title: | Structure of the human telomere in K+ solution: An intramolecular (3 + 1) G-quadruplex scaffold |
| Abstract: | We present the intramolecular G-quadruplex structure of human telomeric DNA in physiologically relevant K+ solution. This G-quadruplex, whose (3 + 1) topology differs from folds reported previously in Na+ solution and in a K+-containing crystal, involves the following: one anti·syn·syn·syn and two syn·anti· anti·anti G-tetrads; one double-chain reversal and two edgewise loops; three G-tracts oriented in one direction and the fourth in the opposite direction. The topological characteristics of this (3 + 1) G-quadruplex scaffold should provide a unique platform for structure-based anticancer drug design targeted to human telomeric DNA. © 2006 American Chemical Society. |
| Keywords: | telomere; dna; guanine; hydrogen bond; models, molecular; solutions; molecular interaction; nucleic acid conformation; structure analysis; biochemistry; oligonucleotide; proton nuclear magnetic resonance; g-quadruplex; human telomere; potassium; anticancer drug; topology; potassium ion; drug dosage; nuclear overhauser effect; sodium ion; positive ions; crystals |
| Journal Title: | Journal of the American Chemical Society |
| Volume: | 128 |
| Issue: | 30 |
| ISSN: | 0002-7863 |
| Publisher: | American Chemical Society |
| Date Published: | 2006-08-02 |
| Start Page: | 9963 |
| End Page: | 9970 |
| Language: | English |
| DOI: | 10.1021/ja062791w |
| PUBMED: | 16866556 |
| PROVIDER: | scopus |
| PMCID: | PMC4692383 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 205" - "Export Date: 4 June 2012" - "CODEN: JACSA" - "Source: Scopus" |
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