In situ maturation and tissue adaptation of type 2 innate lymphoid cell progenitors Journal Article
| Authors: | Zeis, P.; Lian, M.; Fan, X.; Herman, J. S.; Hernandez, D. C.; Gentek, R.; Elias, S.; Symowski, C.; Knöpper, K.; Peltokangas, N.; Friedrich, C.; Doucet-Ladeveze, R.; Kabat, A. M.; Locksley, R. M.; Voehringer, D.; Bajenoff, M.; Rudensky, A. Y.; Romagnani, C.; Grün, D.; Gasteiger, G. |
| Article Title: | In situ maturation and tissue adaptation of type 2 innate lymphoid cell progenitors |
| Abstract: | To investigate how innate lymphoid cells (ILCs) are locally maintained, Zeis et al. generated a single-cell atlas of lung ILCs and tracked Il18r1+ progenitor and effector ILC2s. Their work identifies tissue-resident and circulating ILC progenitors and highlights in situ differentiation and tissue adaptation as a mechanism of ILC renewal and phenotypic diversification. © 2020 Elsevier Inc. Innate lymphoid cells (ILCs) are generated early during ontogeny and persist predominantly as tissue-resident cells. Here, we examined how ILCs are maintained and renewed within tissues. We generated a single cell atlas of lung ILC2s and found that Il18r1+ ILCs comprise circulating and tissue-resident ILC progenitors (ILCP) and effector-cells with heterogeneous expression of the transcription factors Tcf7 and Zbtb16, and CD103. Our analyses revealed a continuous differentiation trajectory from Il18r1+ ST2− ILCPs to Il18r− ST2+ ILC2s, which was experimentally validated. Upon helminth infection, recruited and BM-derived cells generated the entire spectrum of ILC2s in parabiotic and shield chimeric mice, consistent with their potential role in the renewal of tissue ILC2s. Our findings identify local ILCPs and reveal ILCP in situ differentiation and tissue adaptation as a mechanism of ILC maintenance and phenotypic diversification. Local niches, rather than progenitor origin, or the developmental window during ontogeny, may dominantly imprint ILC phenotypes in adult tissues. © 2020 Elsevier Inc. |
| Keywords: | human cell; nonhuman; bone marrow; cell renewal; resident; lung; immunity; progenitors; lymphoid cell; human; article; immune system development; single-cell rna-seq; single cell rna seq; ilc2; ilcp; innate lymphoid cells (ilc); nippostrongylus brasiliensis; single cell atlas; tissue immunity |
| Journal Title: | Immunity |
| Volume: | 53 |
| Issue: | 4 |
| ISSN: | 1074-7613 |
| Publisher: | Cell Press |
| Date Published: | 2020-10-13 |
| Start Page: | 775 |
| End Page: | 792.e9 |
| Language: | English |
| DOI: | 10.1016/j.immuni.2020.09.002 |
| PUBMED: | 33002412 |
| PROVIDER: | scopus |
| PMCID: | PMC7611573 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 2 November 2020 -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work