Mouse cytomegalovirus-experienced ILC1s acquire a memory response dependent on the viral glycoprotein m12 Journal Article

   

Authors:	Weizman, O. E.; Song, E.; Adams, N. M.; Hildreth, A. D.; Riggan, L.; Krishna, C.; Aguilar, O. A.; Leslie, C. S.; Carlyle, J. R.; Sun, J. C.; O’Sullivan, T. E.
Article Title:	Mouse cytomegalovirus-experienced ILC1s acquire a memory response dependent on the viral glycoprotein m12
Abstract:	Innate lymphoid cells (ILCs) are tissue-resident sentinels that are essential for early host protection from pathogens at initial sites of infection. However, whether pathogen-derived antigens directly modulate the responses of tissue-resident ILCs has remained unclear. In the present study, it was found that liver-resident type 1 ILCs (ILC1s) expanded locally and persisted after the resolution of infection with mouse cytomegalovirus (MCMV). ILC1s acquired stable transcriptional, epigenetic and phenotypic changes a month after the resolution of MCMV infection, and showed an enhanced protective effector response to secondary challenge with MCMV consistent with a memory lymphocyte response. Memory ILC1 responses were dependent on the MCMV-encoded glycoprotein m12, and were independent of bystander activation by proinflammatory cytokines after heterologous infection. Thus, liver ILC1s acquire adaptive features in an MCMV-specific manner. © 2019, The Author(s), under exclusive licence to Springer Nature America, Inc.
Journal Title:	Nature Immunology
Volume:	20
Issue:	8
ISSN:	1529-2908
Publisher:	Nature Publishing Group
Date Published:	2019-08-01
Start Page:	1004
End Page:	1011
Language:	English
DOI:	10.1038/s41590-019-0430-1
PUBMED:	31263280
PROVIDER:	scopus
PMCID:	PMC6697419
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85068554192&doi=10.1038%2fs41590-019-0430-1&partnerID=40&md5=fb92a13bea02a4340b259d35cc8b1abd
Notes:	Article -- Source: Scopus

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