Mouse cytomegalovirus-experienced ILC1s acquire a memory response dependent on the viral glycoprotein m12 Journal Article


Authors: Weizman, O. E.; Song, E.; Adams, N. M.; Hildreth, A. D.; Riggan, L.; Krishna, C.; Aguilar, O. A.; Leslie, C. S.; Carlyle, J. R.; Sun, J. C.; O’Sullivan, T. E.
Article Title: Mouse cytomegalovirus-experienced ILC1s acquire a memory response dependent on the viral glycoprotein m12
Abstract: Innate lymphoid cells (ILCs) are tissue-resident sentinels that are essential for early host protection from pathogens at initial sites of infection. However, whether pathogen-derived antigens directly modulate the responses of tissue-resident ILCs has remained unclear. In the present study, it was found that liver-resident type 1 ILCs (ILC1s) expanded locally and persisted after the resolution of infection with mouse cytomegalovirus (MCMV). ILC1s acquired stable transcriptional, epigenetic and phenotypic changes a month after the resolution of MCMV infection, and showed an enhanced protective effector response to secondary challenge with MCMV consistent with a memory lymphocyte response. Memory ILC1 responses were dependent on the MCMV-encoded glycoprotein m12, and were independent of bystander activation by proinflammatory cytokines after heterologous infection. Thus, liver ILC1s acquire adaptive features in an MCMV-specific manner. © 2019, The Author(s), under exclusive licence to Springer Nature America, Inc.
Journal Title: Nature Immunology
Volume: 20
Issue: 8
ISSN: 1529-2908
Publisher: Nature Publishing Group  
Date Published: 2019-08-01
Start Page: 1004
End Page: 1011
Language: English
DOI: 10.1038/s41590-019-0430-1
PUBMED: 31263280
PROVIDER: scopus
PMCID: PMC6697419
DOI/URL:
Notes: Article -- Source: Scopus
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MSK Authors
  1. Joseph C Sun
    130 Sun
  2. Christina Leslie
    187 Leslie
  3. Orrel   Weizman
    11 Weizman
  4. Nicholas M Adams
    19 Adams
  5. Chirag Krishna
    20 Krishna