Fate mapping of single NK cells identifies a type 1 innate lymphoid-like lineage that bridges innate and adaptive recognition of viral infection Journal Article
| Authors: | Flommersfeld, S.; Böttcher, J. P.; Ersching, J.; Flossdorf, M.; Meiser, P.; Pachmayr, L. O.; Leube, J.; Hensel, I.; Jarosch, S.; Zhang, Q.; Chaudhry, M. Z.; Andrae, I.; Schiemann, M.; Busch, D. H.; Cicin-Sain, L.; Sun, J. C.; Gasteiger, G.; Victora, G. D.; Höfer, T.; Buchholz, V. R.; Grassmann, S. |
| Article Title: | Fate mapping of single NK cells identifies a type 1 innate lymphoid-like lineage that bridges innate and adaptive recognition of viral infection |
| Abstract: | Upon viral infection, natural killer (NK) cells expressing certain germline-encoded receptors are selected, expanded, and maintained in an adaptive-like manner. Currently, these are thought to differentiate along a common pathway. However, by fate mapping of single NK cells upon murine cytomegalovirus (MCMV) infection, we identified two distinct NK cell lineages that contributed to adaptive-like responses. One was equivalent to conventional NK (cNK) cells while the other was transcriptionally similar to type 1 innate lymphoid cells (ILC1s). ILC1-like NK cells showed splenic residency and strong cytokine production but also recognized and killed MCMV-infected cells, guided by activating receptor Ly49H. Moreover, they induced clustering of conventional type 1 dendritic cells and facilitated antigen-specific T cell priming early during MCMV infection, which depended on Ly49H and the NK cell-intrinsic expression of transcription factor Batf3. Thereby, ILC1-like NK cells bridge innate and adaptive viral recognition and unite critical features of cNK cells and ILC1s. © 2021 The Author(s) |
| Keywords: | nk cells; mcmv; ilc1; adaptive-like nk cell responses; ilc1-like nk cells; single-cell fate mapping |
| Journal Title: | Immunity |
| Volume: | 54 |
| Issue: | 10 |
| ISSN: | 1074-7613 |
| Publisher: | Cell Press |
| Date Published: | 2021-10-12 |
| Start Page: | 2288 |
| End Page: | 2304.e7 |
| Language: | English |
| DOI: | 10.1016/j.immuni.2021.08.002 |
| PUBMED: | 34437840 |
| PROVIDER: | scopus |
| PMCID: | PMC8528403 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 2 November 2021 -- Source: Scopus |
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