ILC1 confer early host protection at initial sites of viral infection Journal Article

Authors: Weizman, O. E.; Adams, N. M.; Schuster, I. S.; Krishna, C.; Pritykin, Y.; Lau, C.; Degli-Esposti, M. A.; Leslie, C. S.; Sun, J. C.; O'Sullivan, T. E.
Article Title: ILC1 confer early host protection at initial sites of viral infection
Abstract: Infection is restrained by the concerted activation of tissue-resident and circulating immune cells. Whether tissue-resident lymphocytes confer early antiviral immunity at local sites of primary infection prior to the initiation of circulating responses is not well understood. Furthermore, the kinetics of initial antiviral responses at sites of infection remain unclear. Here, we show that tissue-resident type 1 innate lymphoid cells (ILC1) serve an essential early role in host immunity through rapid production of interferon (IFN)-γ following viral infection. Ablation of Zfp683-dependent liver ILC1 lead to increased viral load in the presence of intact adaptive and innate immune cells critical for mouse cytomegalovirus (MCMV) clearance. Swift production of interleukin (IL)-12 by tissue-resident XCR1+ conventional dendritic cells (cDC1) promoted ILC1 production of IFN-γ in a STAT4-dependent manner to limit early viral burden. Thus, ILC1 contribute an essential role in viral immunosurveillance at sites of initial infection in response to local cDC1-derived proinflammatory cytokines. Innate lymphoid cells have a non-redundant role as initial responders to viral infections. © 2017 Elsevier Inc.
Keywords: signal transduction; controlled study; nonhuman; animal cell; mouse; phenotype; animal tissue; infection; dendritic cell; animal experiment; cell lineage; t lymphocyte receptor; molecular evolution; gamma interferon; antigen specificity; cytokine production; innate immunity; real time polymerase chain reaction; virus infection; bone marrow cell; virus replication; adaptive immunity; immunosurveillance; influenza; lymphoid cell; virus titration; plasmacytoid dendritic cell; cross presentation; peritoneal cavity; sendai virus; viral clearance; hydrodynamics; stat4 protein; female; priority journal; article; mcmv; cdc1; ilc1; tissue-resident; innate lymphoid cell 1
Journal Title: Cell
Volume: 171
Issue: 4
ISSN: 0092-8674
Publisher: Cell Press  
Date Published: 2017-11-02
Start Page: 795
End Page: 808.e12
Language: English
DOI: 10.1016/j.cell.2017.09.052
PROVIDER: scopus
PMCID: PMC5687850
PUBMED: 29056343
Notes: Article -- Export Date: 1 December 2017 -- Source: Scopus
Altmetric Score
MSK Authors
  1. Joseph C Sun
    66 Sun
  2. Christina Leslie
    107 Leslie
  3. Nicholas M Adams
    10 Adams
  4. Colleen M Lau
    7 Lau