Tissue residency of innate lymphoid cells in lymphoid and nonlymphoid organs Journal Article


Authors: Gasteiger, G.; Fan, X.; Dikiy, S.; Lee, S. Y.; Rudensky, A. Y.
Article Title: Tissue residency of innate lymphoid cells in lymphoid and nonlymphoid organs
Abstract: Innate lymphoid cells (ILCs) contribute to barrier immunity, tissue homeostasis, and immune regulation at various anatomical sites throughout the body. How ILCs maintain their presence in lymphoid and peripheral tissues thus far has been unclear. We found that in the lymphoid and nonlymphoid organs of adult mice, ILCs are tissue-resident cells that were maintained and expanded locally under physiologic conditions, upon systemic perturbation of immune homeostasis and during acute helminth infection. However, at later time points after infection, cells from hematogenous sources helped to partially replenish the pool of resident ILCs. Thus, ILCs are maintained by self-renewal in broadly different microenvironments and physiological settings. Such an extreme "sedentary" lifestyle is consistent with the proposed roles of ILCs as sentinels and local keepers of tissue function.
Keywords: mus; vermes
Journal Title: Science
Volume: 350
Issue: 6263
ISSN: 0036-8075
Publisher: American Association for the Advancement of Science  
Date Published: 2015-11-20
Start Page: 981
End Page: 985
Language: English
DOI: 10.1126/science.aac9593
PROVIDER: scopus
PUBMED: 26472762
PMCID: PMC4720139
DOI/URL:
Notes: Export Date: 2 December 2015 -- Source: Scopus
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  1. Alexander Rudensky
    156 Rudensky
  2. Sue Yee Lee
    2 Lee
  3. Stanislav Dikiy
    12 Dikiy
  4. Xiying   Fan
    11 Fan