Innate lymphocytes—lineage, localization and timing of differentiation Review


Authors: Kansler, E. R.; Li, M. O.
Review Title: Innate lymphocytes—lineage, localization and timing of differentiation
Abstract: Innate lymphocytes are a diverse population of cells that carry out specialized functions in steady-state homeostasis and during immune challenge. While circulating cytotoxic natural killer (NK) cells have been studied for decades, tissue-resident innate lymphoid cells (ILCs) have only been characterized and studied over the past few years. As ILCs have been largely viewed in the context of helper T-cell biology, models of ILC lineage and function have been founded within this perspective. Notably, tissue-resident innate lymphocytes with cytotoxic potential have been described in an array of tissues, yet whether they are derived from the NK or ILC lineage is only beginning to be elucidated. In this review, we aim to shed light on the identities of innate lymphocytes through the lenses of cell lineage, localization, and timing of differentiation. © 2019, CSI and USTC.
Keywords: human cell; review; cell lineage; resident; lymphocyte; differentiation; identity; human; article
Journal Title: Cellular & Molecular Immunology
Volume: 16
Issue: 7
ISSN: 1672-7681
Publisher: Nature Publishing Group  
Date Published: 2019-07-01
Start Page: 627
End Page: 633
Language: English
DOI: 10.1038/s41423-019-0211-7
PUBMED: 30804475
PROVIDER: scopus
PMCID: PMC6804950
DOI/URL:
Notes: Review -- Source: Scopus
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  1. Ming Li
    110 Li
  2. Emily Rose Kansler
    10 Kansler