Hallmarks of tissue-resident lymphocytes Journal Article
| Authors: | Fan, X.; Rudensky, A. Y. |
| Article Title: | Hallmarks of tissue-resident lymphocytes |
| Abstract: | Although they are classically viewed as continuously recirculating through the lymphoid organs and blood, lymphocytes also establish residency in non-lymphoid tissues, most prominently at barrier sites, including the mucosal surfaces and skin. These specialized tissue-resident lymphocyte subsets span the innate-adaptive continuum and include innate lymphoid cells (ILCs), unconventional T cells (e.g., NKT, MAIT, γδ T cells, and CD8αα+ IELs), and tissue-resident memory T (TRM) cells. Although these diverse cell types differ in the particulars of their biology, they nonetheless exhibit important shared features, including a role in the preservation of tissue integrity and function during homeostasis, infection, and non-infectious perturbations. In this Review, we discuss the hallmarks of tissue-resident innate, innate-like, and adaptive lymphocytes, as well as their potential functions in non-lymphoid organs. © 2016 Elsevier Inc. |
| Journal Title: | Cell |
| Volume: | 164 |
| Issue: | 6 |
| ISSN: | 0092-8674 |
| Publisher: | Cell Press |
| Date Published: | 2016-03-10 |
| Start Page: | 1198 |
| End Page: | 1211 |
| Language: | English |
| DOI: | 10.1016/j.cell.2016.02.048 |
| PROVIDER: | scopus |
| PUBMED: | 26967286 |
| PMCID: | PMC4973889 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 4 April 2016 -- Source: Scopus |
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