Multilayered immunity by tissue-resident lymphocytes in cancer Review

  


Authors: Li, M. O.; Zhang, J.; Xu, Z.; Zhang, X.; Li, P.; Cornish, A. E.
Review Title: Multilayered immunity by tissue-resident lymphocytes in cancer
Abstract: Lymphocytes spanning the entire innate-adaptive spectrum can stably reside in tissues and constitute an integral component of the local defense network against immunological challenges. In tight interactions with the epithelium and endothelium, tissue-resident lymphocytes sense antigens and alarmins elicited by infectious microbes and abiotic stresses at barrier sites and mount effector responses to restore tissue homeostasis. Of note, such a host cell-directed immune defense system has been recently demonstrated to surveil epithelial cell transformation and carcinoma development, as well as cancer cell metastasis at selected distant organs, and thus represents a primordial cancer immune defense module. Here we review how distinct lineages of tissue-resident innate lymphoid cells, innate-like T cells, and adaptive T cells participate in a form of multilayered cancer immunity in murine models and patients, and how their convergent effector programs may be targeted through both shared and private regulatory pathways for cancer immunotherapy.
Keywords: neoplasm; neoplasms; animal; metabolism; animals; immunology; immunotherapy; carcinoma; innate immunity; immunity, innate; adaptive immunity; immunosurveillance; lymphocyte; lymphocytes; therapy; tumor microenvironment; procedures; innate lymphoid cells; humans; human; innate-like t cells; tissue residence; adaptive t cells
Journal Title: Annual Review of Immunology
Volume: 42
ISSN: 0732-0582
Publisher: Annual Reviews  
Date Published: 2024-01-01
Start Page: 647
End Page: 677
Language: English
DOI: 10.1146/annurev-immunol-083122-043836
PUBMED: 38424658
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85197343021&doi=10.1146%2fannurev-immunol-083122-043836&partnerID=40&md5=e62ea7a7990b538b027e4134c1b136a9
Notes: Source: Scopus
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MSK Authors
  1. Ming Li
    110 Li
  2. Andrew Erickson Cornish
    5 Cornish
  3. Xian Zhang
    11 Zhang
  4. Peng Li
    6 Li
  5. Jing Zhang
    5 Zhang
  6. Zijian Xu
    1 Xu
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