Tissue-resident lymphocytes: Sentinel of the transformed tissue Journal Article

   


Authors: Dadi, S.; Li, M. O.
Article Title: Tissue-resident lymphocytes: Sentinel of the transformed tissue
Abstract: Tumor cells can be detected and cleared by lymphocytes in a process termed cancer immunosurveillance. However, the contributing cell types had not been fully characterized. Using oncogene-induced murine models of epithelial cancer, a recent study showed that cell transformation triggers expansion of tissue-resident lymphocytes derived from innate, T cell receptor (TCR) αβ and TCRγδ lineages. These type-1-like innate lymphoid cells (ILC1ls) and type 1 innate-like T cells (ILTC1s) share a gene expression program distinct from those of conventional lymphocytes, and exhibit cytolytic activities against tumor cells. Further deciphering such a tumor-elicited immunosurveillance mechanism may 1 day be harnessed for novel cancer immunotherapy. © 2017 The Author(s).
Keywords: cancer immunosurveillance; innate lymphoid cells; innate-like t cells
Journal Title: Journal for ImmunoTherapy of Cancer
Volume: 5
Issue: 1
ISSN: 2051-1426
Publisher: Biomed Central Ltd  
Date Published: 2017-05-16
Start Page: 41
Language: English
DOI: 10.1186/s40425-017-0244-3
PROVIDER: scopus
PMCID: PMC5433173
PUBMED: 28515941
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85019268603&doi=10.1186%2fs40425-017-0244-3&partnerID=40&md5=3b84c49dd5df290cda78248b21fef4f7
Notes: Note -- Export Date: 2 June 2017 -- Source: Scopus
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MSK Authors
  1. Ming Li
    110 Li
  2. Saida Dadi
    8 Dadi
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