Cancer immunosurveillance by tissue-resident innate lymphoid cells and innate-like T cells Journal Article

Authors: Dadi, S.; Chhangawala, S.; Whitlock, B. M.; Franklin, R. A.; Luo, C. T.; Oh, S. A.; Toure, A.; Pritykin, Y.; Huse, M.; Leslie, C. S.; Li, M. O.
Article Title: Cancer immunosurveillance by tissue-resident innate lymphoid cells and innate-like T cells
Abstract: Summary Malignancy can be suppressed by the immune system in a process termed immunosurveillance. However, to what extent immunosurveillance occurs in spontaneous cancers and the composition of participating cell types remains obscure. Here, we show that cell transformation triggers a tissue-resident lymphocyte response in oncogene-induced murine cancer models. Non-circulating cytotoxic lymphocytes, derived from innate, T cell receptor (TCR)αβ, and TCRγδ lineages, expand in early tumors. Characterized by high expression of NK1.1, CD49a, and CD103, these cells share a gene-expression signature distinct from those of conventional NK cells, T cells, and invariant NKT cells. Generation of these lymphocytes is dependent on the cytokine IL-15, but not the transcription factor Nfil3 that is required for the differentiation of tumor-infiltrating NK cells, and IL-15 deficiency, but not Nfil3 deficiency, results in accelerated tumor growth. These findings reveal a tumor-elicited immunosurveillance mechanism that engages unconventional type-1-like innate lymphoid cells and type 1 innate-like T cells. © 2016 Elsevier Inc.
Keywords: controlled study; protein expression; unclassified drug; nonhuman; animal cell; mouse; animal tissue; gene expression; animal experiment; animal model; transcription factor; tumor antigen; cell lineage; oncogene; lymphocyte differentiation; granzyme b; t lymphocyte receptor beta chain; t lymphocyte receptor gamma chain; immune response; cell transformation; cytotoxic t lymphocyte; natural killer cell; innate immunity; tumor growth; immunosurveillance; interleukin 15; natural killer t cell; t lymphocyte receptor alpha chain; t lymphocyte receptor delta chain; cytotoxic lymphocyte; lymphoid cell; cancer immunology; precancer; cd103 antigen; priority journal; article; transcription factor nfil3; alpha1 integrin; nk1.1 protein
Journal Title: Cell
Volume: 164
Issue: 3
ISSN: 0092-8674
Publisher: Cell Press  
Date Published: 2016-01-28
Start Page: 365
End Page: 377
Language: English
DOI: 10.1016/j.cell.2016.01.002
PROVIDER: scopus
PMCID: PMC4733424
PUBMED: 26806130
Notes: Article -- Export Date: 3 March 2016 -- Source: Scopus
Altmetric Score
MSK Authors
  1. Morgan Huse
    36 Huse
  2. Christina Leslie
    107 Leslie
  3. Ming Li
    65 Li
  4. Soyoung Oh
    11 Oh
  5. Chong Luo
    9 Luo
  6. Saida   Dadi
    5 Dadi
  7. Ahmed   Toure
    6 Toure