Classification and risk assessment in AML: Integrating cytogenetics and molecular profiling Journal Article

   


Authors: Moarii, M.; Papaemmanuil, E.
Article Title: Classification and risk assessment in AML: Integrating cytogenetics and molecular profiling
Abstract: In recent years, the composite molecular architecture in acute myeloid leukemia (AML) has been mapped out. We now have a clearer understanding of the key genetic determinants, the major genetic interactions, and the broad order in which these mutations occur. The next impending challenge is to discern how these recent genomic discoveries define disease biology as well as how to use molecular markers to deliver patient-tailored clinical decision support.
Keywords: diagnosis; recommendations; acute promyelocytic leukemia; stem-cells; acute myeloid-leukemia; somatic mutations; international; world-health-organization; clonal hematopoiesis; prognostic relevance; expert panel
Journal Title: Hematology-American Society of Hematology Education Program
Volume: 2017
ISSN: 1520-4391
Publisher: American Society of Hematology  
Date Published: 2017-12-08
Start Page: 37
End Page: 44
Language: English
ACCESSION: WOS:000432655400005
DOI: 10.1182/asheducation-2017.1.37
PROVIDER: wos
PUBMED: 29222235
PMCID: PMC6142605
Notes: Article -- Source: Wos
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MSK Authors
  1. Elli Papaemmanuil
    206 Papaemmanuil
  2. Matahi Wilfrid Serge Moarii
    7 Moarii
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