The head and neck cancer genome in the era of immunotherapy Review

  


Authors: Wijetunga, N. A.; Yu, Y.; Morris, L. G.; Lee, N.; Riaz, N.
Review Title: The head and neck cancer genome in the era of immunotherapy
Abstract: The recent success of immunotherapy in head and neck squamous cell carcinoma (HNSCC) has necessitated a new perspective on the cancer genome. Here we review recent advances in the carcinogenesis and molecular genetics of HNSCC with an eye on their implications for cancer immunity. Newer sequencing technologies have recently facilitated dissection of the complex interaction between the HPV virus, tumor, host factors, and the tumor microenvironment (TME) that help shed light on how the immune system interacts with head and neck malignancies. © 2020 Elsevier Ltd
Keywords: immunotherapy; genomics; sequencing; hnscc; immune infiltration; neoantigens; immunogenomics; hpv-infection; immune-evasion; tobacco-use
Journal Title: Oral Oncology
Volume: 112
ISSN: 1368-8375
Publisher: Elsevier Inc.  
Date Published: 2021-01-01
Start Page: 105040
Language: English
DOI: 10.1016/j.oraloncology.2020.105040
PROVIDER: scopus
PUBMED: 33197752
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85095934408&doi=10.1016%2fj.oraloncology.2020.105040&partnerID=40&md5=c7692eb33aa7156bf9af6f65f2247abd
Notes: Review -- Export Date: 1 December 2020 -- Source: Scopus
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MSK Authors
  1. Nadeem Riaz
    415 Riaz
  2. Nancy Y. Lee
    871 Lee
  3. Luc Morris
    278 Morris
  4. Yao Yu
    112 Yu
  5. Neil Ari Wijetunga
    53 Wijetunga
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