JAVELIN Head and Neck 100: A Phase III trial of avelumab and chemoradiation for locally advanced head and neck cancer Journal Article
| Authors: | Yu, Y.; Lee, N. Y. |
| Article Title: | JAVELIN Head and Neck 100: A Phase III trial of avelumab and chemoradiation for locally advanced head and neck cancer |
| Abstract: | Chemoradiotherapy (CRT) is the standard of care for locoregionally advanced squamous cell carcinomas of the head and neck (HNSCC). The immune checkpoint inhibitors nivolumab and pembrolizumab were recently approved by the US FDA for treatment of recurrent or metastatic HNSCC that are refractory to platinum chemotherapy. However, prospective studies incorporating immune checkpoint inhibitors in the definitive management of poor prognosis, nonmetastatic, locoregionally advanced HNSCC are lacking. The JAVELIN Head and Neck 100 study is a multinational, Phase III, double-blind, placebo-controlled, randomized clinical trial assessing the efficacy of avelumab, a PD-L1 inhibitor, in combination with CRT compared with placebo in combination with CRT for high-risk HNSCC. Trial registration: Javelin Head and Neck 100; NCT 02952586. © 2018 2018 Future Medicine Ltd. |
| Keywords: | immunotherapy; locally advanced; head and neck; chemoradiotherapy; pd-1; pd-l1; immune checkpoint blockade |
| Journal Title: | Future Oncology |
| Volume: | 15 |
| Issue: | 7 |
| ISSN: | 1479-6694 |
| Publisher: | Future Medicine |
| Date Published: | 2019-03-01 |
| Start Page: | 687 |
| End Page: | 694 |
| Language: | English |
| DOI: | 10.2217/fon-2018-0405 |
| PUBMED: | 30461306 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 April 2019 -- Source: Scopus |
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