Trends in chemoradiation use in elderly patients with head and neck cancer: Changing treatment patterns with cetuximab Journal Article

   


Authors: Baxi, S. S.; O'Neill, C.; Sherman, E. J.; Atoria, C. L.; Lee, N. Y.; Pfister, D. G.; Elkin, E. B.
Article Title: Trends in chemoradiation use in elderly patients with head and neck cancer: Changing treatment patterns with cetuximab
Abstract: Background. Cetuximab was approved for use in chemoradiation therapy (CRT) for locally advanced head and neck squamous cell carcinoma (HNSCC) in 2006. Methods. Among 3705 patients with locally advanced HNSCC identified in the linked Surveillance Epidemiology and End Results (SEER) Medicare database, we assessed treatment trends, including surgery, radiation therapy (RT), CRT, and specific agents used in CRT. We examined the influence of demographic and clinical characteristics on the likelihood of receiving CRT before and after 2006. Results. Chemoradiation use increased from 29% of patients diagnosed in 2001 to 61% in 2009 (p < .0001). Compared to before 2006, neither age nor comorbidity score was associated with receipt of CRT after 2006. Platinum combinations were the most commonly used concurrent chemotherapies before 2006, but, since then, cetuximab has become the most commonly used agent. Conclusion. The use of CRT has increased substantially and cetuximab may have increased CRT use, especially in older and sicker patients. (C) 2015 Wiley Periodicals, Inc.
Keywords: squamous cell carcinoma; chemotherapy; radiotherapy; cetuximab; head and neck cancer; carcinoma; chemoradiation; concurrent; squamous-cell carcinoma; radiation-therapy; randomized-trial; adverse events; locally advanced head; population-based; laryngeal-cancer; stage oropharynx
Journal Title: Head & Neck
Volume: 38
ISSN: 1043-3074
Publisher: John Wiley & Sons, Inc.  
Date Published: 2016-04-01
Start Page: E165
End Page: E171
Language: English
ACCESSION: WOS:000375116400004
DOI: 10.1002/hed.23961
PROVIDER: wos
PUBMED: 25535104
PMCID: PMC4970459
Notes: Article -- Source: Wos
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MSK Authors
  1. Eric J Sherman
    339 Sherman
  2. Elena B Elkin
    163 Elkin
  3. Nancy Y. Lee
    871 Lee
  4. David G Pfister
    389 Pfister
  5. Shrujal S Baxi
    106 Baxi
  6. Coral Lynn Atoria
    51 Atoria
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