Genetic/familial high-risk assessment: Breast and ovarian - Clinical Practice Guidelines in Oncology™ Journal Article

  


Authors: Daly, M. B.; Axilbund, J. E.; Bryant, E.; Buys, S.; Eng, C.; Friedman, S.; Esserman, L. J.; Farrell, C. D.; Ford, J. M.; Garber, J. E.; Jeter, J. M.; Kohlmann, W.; Lynch, P. M.; Marcom, P. K.; Nabell, L. M.; Offit, K.; Osarogiagbon, R. U.; Pasche, B.; Reiser, G.; Sutphen, R.; Weitzel, J. N.
Article Title: Genetic/familial high-risk assessment: Breast and ovarian - Clinical Practice Guidelines in Oncology™
Abstract: Recent advances in molecular genetics have identified several genes associated with inherited susceptibility to cancer and have provided a means to begin identifying individuals and families with an increased risk of cancer. This rapid expansion of knowledge about cancer genetics has implications for all aspects of cancer management, including prevention, screening, and treatment. These guidelines specifically address hereditary breast/ovarian cancer syndrome (HBOC), Li-Fraumeni syndrome, and Cowden syndrome. These guidelines were developed understanding that much of our knowledge of how the rapidly emerging field of molecular genetics can be applied clinically is preliminary and that flexibility is needed when applying these guidelines to individual families. © Journal of the National Comprehensive Cancer Network.
Keywords: gene mutation; genetics; review; anamnesis; cancer risk; salpingooophorectomy; gene; familial disease; heredity; ovary cancer; breast cancer; mastectomy; nccn clinical practice guidelines; brca1 protein; brca2 protein; protein p53; risk assessment; gene mapping; screening; family history; phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase; familial cancer; li-fraumeni syndrome; hormone; genetic screening; brca1; brca2; chromosome 17; cowden syndrome; genetic linkage; genetic counseling; hereditary; hormone substitution; autosomal dominant inheritance; pedigree analysis; breast/ovarian cancer syndrome; genetic risk assessment
Journal Title: Journal of the National Comprehensive Cancer Network
Volume: 4
Issue: 2
ISSN: 1540-1405
Publisher: Harborside Press  
Date Published: 2006-02-01
Start Page: 156
End Page: 176
Language: English
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-33646834238&partnerID=40&md5=481ee4ed84aef14bfc49944cecbf3488
Notes: --- - "Cited By (since 1996): 21" - "Export Date: 4 June 2012" - "Source: Scopus"