Mouse models of cancer as biological filters for complex genomic data Journal Article
| Authors: | Oricchio, E.; Wolfe, A. L.; Schatz, J. H.; Mavrakis, K. J.; Wendel, H. G. |
| Article Title: | Mouse models of cancer as biological filters for complex genomic data |
| Abstract: | Genetically and pathologically accurate mouse models of leukemia and lymphoma have been developed in recent years. Adoptive transfer of genetically modified hematopoietic progenitor cells enables rapid and highly controlled gain- and loss-of-function studies for these types of cancer. In this Commentary, we discuss how these highly versatile experimental approaches can be used as biological filters to pinpoint transformation-relevant activities from complex cancer genome data. We anticipate that the functional identification of genetic 'drivers' using mouse models of leukemia and lymphoma will facilitate the development of molecular diagnostics and mechanism-based therapies for patients that suffer from these diseases. |
| Keywords: | leukemia; nonhuman; note; genetic analysis; animals; mice; experimental mouse; hematologic neoplasms; lymphoma; genomics; genome; disease models, animal; disease predisposition; genetic screening; translational research; databases, genetic; genetic transformation; biofilter |
| Journal Title: | Disease Models & Mechanisms |
| Volume: | 3 |
| Issue: | 11-12 |
| ISSN: | 1754-8403 |
| Publisher: | Company of Biologists |
| Date Published: | 2010-11-01 |
| Start Page: | 701 |
| End Page: | 704 |
| Language: | English |
| DOI: | 10.1242/dmm.006296 |
| PUBMED: | 20876355 |
| PROVIDER: | scopus |
| PMCID: | PMC2965398 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 20 April 2011" - "Source: Scopus" |
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