Modelling haematopoietic malignancies in the mouse and therapeutical implications Journal Article
| Authors: | Bernardi, R.; Grisendi, S.; Pandolfi, P. P. |
| Article Title: | Modelling haematopoietic malignancies in the mouse and therapeutical implications |
| Abstract: | Modelling human disease in the mouse has become an essential activity in biomedical research in order to unravel molecular mechanisms underlying pathological conditions as well as to determine in vivo the consequences of aberrant gene function. The mouse is by far the most accessible mammalian system physiologically similar to humans. Furthermore, the development of novel techniques for manipulating the murine genome, which allow the in vivo modification of virtually any genomic region in a time and/or tissue specific manner, renders the mouse an ideal model system to study human pathological conditions. Modelling human diseases in mice has reached an even greater relevance in the field of haematological malignancies, due to the already advanced characterization of the molecular basis of many haematological disorders. In this review, we describe the most important technological developments that made it possible to reproduce in the mouse the genetic lesions that characterize human haematological malignancies, thus often generating faithful mouse models of the human condition. We provide specific examples of the advantages and limitations of the various genetic approaches utilized to model leukaemia and lymphoma in the mouse. Finally, we discuss the power of mouse modelling in developing and testing novel therapeutic modalities in pre-clinical studies. |
| Keywords: | leukemia; promoter region; histone deacetylase inhibitor; clinical trial; nonhuman; mouse; mammalia; animals; mice; imatinib; proto oncogene; protein bcl 2; gene expression; models, biological; animal model; genetic transcription; chronic myeloid leukemia; transgenic mouse; animalia; mus musculus; mice, transgenic; protein tyrosine kinase inhibitor; arsenic trioxide; leukemia, promyelocytic, acute; t cell lymphoma; nonhodgkin lymphoma; hematologic neoplasms; dna; hybrid protein; lymphoma; protein farnesyltransferase inhibitor; promyelocytic leukemia; transgene; murinae; vorinostat; chromosome translocation; phase 1 clinical trial; acute lymphocytic leukemia; disease models, animal; tetracycline; t cell leukemia; retinoic acid; fusion proteins, bcr-abl; transgenic mice; trichostatin a; animal models; knock-in; tissue specificity; hematopoietic system tumor; retinoic acid receptor; recombinase; lonafarnib; humans; human; priority journal; article; cre-loxp system; leukaemias and lymphomas; tetracycline-inducible system |
| Journal Title: | Oncogene |
| Volume: | 21 |
| Issue: | 21 |
| ISSN: | 0950-9232 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2002-05-13 |
| Start Page: | 3445 |
| End Page: | 3458 |
| Language: | English |
| DOI: | 10.1038/sj.onc.1205313 |
| PUBMED: | 12032781 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 14 November 2014 -- Source: Scopus |
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