Mouse modeling in oncologic preclinical and translational research Journal Article
| Authors: | Carver, B. S.; Pandolfi, P. P. |
| Article Title: | Mouse modeling in oncologic preclinical and translational research |
| Abstract: | Through scientific and technological advancements, our ability to manipulate the mouse genome has allowed us to evaluate the effect of specific genetic alterations on in vivo tumorigenesis. This has allowed and will allow us to define molecular pathways describing the processes of tumor initiation, invasion, and progression to metastatic disease. Additionally, these models may serve as an excellent platform for the identification of novel molecular targets for therapy as well as to evaluate the efficacy of targeted therapies. Ultimately this will translate from preclinical mouse model trials to the development of clinical trials and protocols for cancer patients. Here we review the usefulness of mouse modeling in oncologic translational research. © 2006 American Association for Cancer Research. |
| Keywords: | protein kinase b; gene mutation; gene deletion; clinical trial; review; nonhuman; neoplasms; mouse; animals; mice; gene targeting; metastasis; breast cancer; models, biological; lung non small cell cancer; clinical protocol; in vivo study; xenograft model antitumor assays; drug evaluation, preclinical; drug design; cancer research; carcinogenesis; mice, transgenic; prostate cancer; cancer invasion; prostatic neoplasms; cancer inhibition; leukemia, promyelocytic, acute; genetic engineering; phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase; pten phosphohydrolase; gefitinib; promyelocytic leukemia; tamoxifen; genome; tumor growth; disease models, animal; rapamycin; multipotent stem cells; oncogene protein v-akt |
| Journal Title: | Clinical Cancer Research |
| Volume: | 12 |
| Issue: | 18 |
| ISSN: | 1078-0432 |
| Publisher: | American Association for Cancer Research |
| Date Published: | 2006-09-15 |
| Start Page: | 5305 |
| End Page: | 5311 |
| Language: | English |
| DOI: | 10.1158/1078-0432.ccr-06-0482 |
| PUBMED: | 17000663 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 27" - "Export Date: 4 June 2012" - "CODEN: CCREF" - "Source: Scopus" |
