Using mice to decipher the molecular genetics of brain tumors Journal Article
| Authors: | Hesselager, G.; Holland, E. C. |
| Article Title: | Using mice to decipher the molecular genetics of brain tumors |
| Abstract: | THE PAST DECADE has dramatically increased our knowledge of genetic and molecular alterations in human central nervous system tumors. Important as these alterations are for the molecular classification of tumors, their actual roles in tumorigenesis and tumor progression have long remained obscure. Lately, several mouse brain tumor models have been developed that use different gene modification strategies to replicate mutations seen in the human counterpart. These genetic models will allow discrimination between mutations that are causally related to tumor formation and mutations that are a result of tumor progression. These models also provide histologically and genetically accurate models for preclinical testing and will perhaps help us identify novel targets for therapies aimed at the mechanistic cause of the disease. We present here a review of current models, with a focus on gliomas and medulloblastomas. |
| Keywords: | protein kinase b; gene mutation; human cell; mutation; clinical trial; disease course; histopathology; review; erlotinib; nonhuman; molecular genetics; brain tumor; glioma; brain neoplasms; animal cell; mouse; animals; mice; imatinib; stem cell factor; epidermal growth factor receptor; platelet derived growth factor receptor; central nervous system tumor; carcinogenesis; temsirolimus; disease model; dna modification; medulloblastoma; gefitinib; tipifarnib; ras protein; tumor model; bcr abl protein; molecular biology; mouse models; disease models, animal; tumor classification; transgenic mice; brain tumors; gene replication; humans; human; priority journal |
| Journal Title: | Neurosurgery |
| Volume: | 53 |
| Issue: | 3 |
| ISSN: | 0148-396X |
| Publisher: | Wolters Kluwer |
| Date Published: | 2003-09-01 |
| Start Page: | 685 |
| End Page: | 694 |
| Language: | English |
| PUBMED: | 12943584 |
| PROVIDER: | scopus |
| DOI: | 10.1227/01.NEU.0000081304.57547.B5 |
| DOI/URL: | |
| Notes: | Export Date: 25 September 2014 -- Source: Scopus |
