Mechanisms of gene regulation by vitamin D(3) receptor: A network of coactivator interactions Journal Article
| Authors: | Rachez, C.; Freedman, L. P. |
| Article Title: | Mechanisms of gene regulation by vitamin D(3) receptor: A network of coactivator interactions |
| Abstract: | The vitamin D3 receptor regulates transcription in direct response to its cognate hormonal ligand, 1,25(OH)2D3. Ligand binding leads to the recruitment of coactivators. Many of these factors, acting in large complexes, have emerged as chromatin remodelers partly through intrinsic histone modifying activities. In addition, other ligand-recruited complexes appear to act more directly on the transcriptional appartus, suggesting that transcriptional regulation by VDR and other nuclear receptors may involve a process of both chromatin alterations and direct recruitment of key initiation components at regulated promoters. (C) 2000 Elsevier Science B.V. All rights reserved. |
| Keywords: | signal transduction; unclassified drug; promoter region; review; nonhuman; mammalia; animals; genetic transcription; gene expression regulation; transcription regulation; drug mechanism; histone; chromatin; mammal; transcription; gene control; yeast; protein structure; cell nucleus receptor; vitamin d receptor; colecalciferol; trans-activation (genetics); colecalciferol receptor; receptors, calcitriol; humans; priority journal; cbp/p300; drip; src-1; 1,25(oh)2d3 |
| Journal Title: | Gene |
| Volume: | 246 |
| Issue: | 1-2 |
| ISSN: | 0378-1119 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 2000-04-04 |
| Start Page: | 9 |
| End Page: | 21 |
| Language: | English |
| DOI: | 10.1016/s0378-1119(00)00052-4 |
| PUBMED: | 10767523 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Export Date: 23 September 2016 -- Source: Scopus |
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