Nuclear receptor cofactors as chromatin remodelers Journal Article
| Authors: | Lemon, B. D.; Freedman, L. P. |
| Article Title: | Nuclear receptor cofactors as chromatin remodelers |
| Abstract: | Nuclear receptors regulate transcription in direct response to their cognate hormonal ligands. Ligand binding leads to the dissociation of corepressors and the recruitment of coactivators. Many of these factors, acting in large complexes, have emerged as chromatin remodelers through intrinsic histone modifying activities or through other novel functions. In addition, other ligand-recruited complexes appear to act more directly on the transcriptional apparatus, suggesting that transcriptional regulation by nuclear receptors may involve a process of both chromatin alterations and direct recruitment of key initiation components at regulated promoters. |
| Keywords: | human cell; promoter region; review; nonhuman; animal cell; animals; animalia; transcription regulation; histone; chromatin; adenosine triphosphate; cell nucleus receptor; histones; ligand binding; chromatin structure; receptors, cytoplasmic and nuclear; humans; human; priority journal |
| Journal Title: | Current Opinion in Genetics and Development |
| Volume: | 9 |
| Issue: | 5 |
| ISSN: | 0959-437X |
| Publisher: | Elsevier Inc. |
| Date Published: | 1999-10-01 |
| Start Page: | 499 |
| End Page: | 504 |
| Language: | English |
| DOI: | 10.1016/s0959-437x(99)00010-6 |
| PUBMED: | 10508693 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Export Date: 16 August 2016 -- Source: Scopus |
