Strategies for transcriptional activation by steroid/nuclear receptors Journal Article
| Author: | Freedman, L. P. |
| Article Title: | Strategies for transcriptional activation by steroid/nuclear receptors |
| Abstract: | Nuclear receptors regulate transcription in direct response to their cognate hormonal ligands. Ligand binding leads to the dissociation of corepressors and the recruitment of coactivators. Many of these factors, acting in large complexes, have emerged as chromatin remodelers through intrinsic histone-modifying activities or through other novel functions. In addition, other ligand-recruited complexes appear to act more directly on the transcriptional apparatus, suggesting that transcriptional regulation by nuclear receptors may involve a process of both chromatin alterations and direct recruitment of key initiation components at regulated promoters. |
| Keywords: | genetics; review; protein domain; animal; metabolism; animals; protein protein interaction; transcription initiation; histone; chromatin; ligand; transactivation; transcription; ligands; protein family; cell nucleus receptor; steroid receptor; receptors, steroid; rna polymerase ii; histones; ligand binding; receptors, cytoplasmic and nuclear; cell receptor; trans-activation (genetics); humans; human; priority journal; article |
| Journal Title: | Journal of Cellular Biochemistry |
| Volume: | 76 |
| Issue: | Suppl. |
| ISSN: | 0730-2312 |
| Publisher: | John Wiley & Sons |
| Date Published: | 1999-01-01 |
| Start Page: | 103 |
| End Page: | 109 |
| Language: | English |
| PUBMED: | 10629109 |
| PROVIDER: | scopus |
| DOI: | 10.1002/(SICI)1097-4644(1999)75:32+<103::AID-JCB13>3.0.CO;2-W |
| DOI/URL: | |
| Notes: | Article -- Export Date: 16 August 2016 -- Source: Scopus |
