Multimeric coactivator complexes for steroid/nuclear receptors Conference Paper
| Author: | Freedman, L. P. |
| Title: | Multimeric coactivator complexes for steroid/nuclear receptors |
| Conference Title: | 12th European Workshop on Molecular and Cellular Endocrinology of the Testis |
| Abstract: | Nuclear receptors regulate transcription in direct response to their cognate hormonal ligands. Ligand-binding leads to the dissociation of corepressors and the recruitment of coactivators. Many of these factors, acting in large complexes, have emerged as chromatin remodelers through intrinsic histone-modifying activities or through other novel functions. In addition, other ligand-recruited complexes appear to act more directly on the transcriptional apparatus, suggesting that transcriptional regulation by nuclear receptors may involve a process of both chromatin alterations and direct recruitment of key initiation components at regulated promoters. |
| Keywords: | nuclear receptors; transcriptional activation; histone deacetylase; acetylation; rna-polymerase-ii; estrogen-receptor; binding; thyroid-hormone receptor; ppar-gamma; n-cor |
| Journal Title | Ernst Schering Foundation Symposium Proceedings |
| Conference Dates: | 2002 Apr 6-10 |
| Conference Location: | Doorwerth, Netherlands |
| ISBN: | 0947-6075 |
| Publisher: | Springer Verlag |
| Date Published: | 2002-01-01 |
| Start Page: | 139 |
| End Page: | 149 |
| Language: | English |
| ACCESSION: | WOS:000176702200010 |
| PROVIDER: | wos |
| DOI: | 10.1007/978-3-662-05066-8_10 |
| Notes: | Chapter 10 in "Testicular Tangrams" (ISBN: 978-3-662-05068-2) -- Source: Wos |
