Multimeric coactivator complexes for steroid/nuclear receptors Journal Article
| Author: | Freedman, L. P. |
| Article Title: | Multimeric coactivator complexes for steroid/nuclear receptors |
| Abstract: | Nuclear receptors regulate transcription in direct response to their cognate hormonal ligands. Ligand binding leads to the dissociation of corepressors and the recruitment of coactivators. Many of these factors, acting in large complexes, have emerged as chromatin remodelers through intrinsic histone-modifying activities or through other novel functions. In addition, other ligand-recruited complexes appear to act more directly on the transcriptional apparatus, suggesting that transcriptional regulation by nuclear receptors might involve a process of both chromatin alterations and direct recruitment of key initiation components at regulated promoters. |
| Keywords: | promoter region; review; cell differentiation; transcription regulation; growth regulation; hormonal regulation; cell nucleus receptor; chromatin structure; hormone receptor interaction; priority journal |
| Journal Title: | Trends in Endocrinology and Metabolism |
| Volume: | 10 |
| Issue: | 10 |
| ISSN: | 1043-2760 |
| Publisher: | Elsevier Inc. |
| Date Published: | 1999-12-01 |
| Start Page: | 403 |
| End Page: | 407 |
| Language: | English |
| DOI: | 10.1016/s1043-2760(99)00208-8 |
| PROVIDER: | scopus |
| PUBMED: | 10542397 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 16 August 2016 -- Source: Scopus |
