Immunohistochemical localization of a carboxy terminus epitope of the novel mu opioid receptor splice variant MOR-1C within the human spinal cord Meeting Abstract

  


Authors: Abbadie, C.; Gultekin, S. H.; Pasternak, G. W.
Abstract Title: Immunohistochemical localization of a carboxy terminus epitope of the novel mu opioid receptor splice variant MOR-1C within the human spinal cord
Meeting Title: 30th Meeting of the Society for Neuroscience
Abstract: The present study examined immunohistochemically the distribution in the human spinal cord of a splice variant of the mu opioid receptor, MOR-1C, using a rabbit antiserum generated against a unique epitope from this new carboxy terminus sequence. MOR-1C-like immunoreactivity (-LI) was particularly abundant in the superficial laminae of the dorsal horn and around the central canal. In the substantia gelatinosa, MOR-1C-LI appeared in small diameter axonal elements as well as in the cytoplasm and plasmalemma of small spinal neurons and dendrites in inner lamina II. Some MOR-1C-LI fibers were also observed in the Lissauer's tract. Comparatively in the human cord, mu opioid receptor-LI (MOR-1-LI) and delta opioid receptor-LI (DOR-1-LI) were only observed in the superficial laminae. MOR-1-LI appeared to be diffuse whereas MOR-1C-LI and DOR-1-LI were in thin beaded processes that are probably axonal. We showed that the opioid receptors distribution differed in the spinal cord where they might play a role in the control of pain processing.
Keywords: control; meeting abstract; pain processing
Journal Title: Society for Neuroscience Abstracts
Volume: 26
Issue: Part 1
Meeting Dates: 2000 Nov 4-9
Meeting Location: New Orleans, LA
ISSN: 0190-5295
Publisher: Society for Neuroscience  
Date Published: 2000-01-01
Start Page: 658
Language: English
ACCESSION: BCI:BCI200100077036
PROVIDER: biosis
Notes: Meeting Abstract: 246.15 -- 30th Annual Meeting of the Society of Neuroscience -- New Orleans, LA, USA -- November 04-09, 2000 -- Society for Neuroscience -- Source: Biosis