Immunohistochemical localization of the carboxy terminus of the novel mu opioid receptor splice variant MOR-IC within the human spinal cord Journal Article

  


Authors: Abbadie, C.; Gultekin, S. H.; Pasternak, G. W.
Article Title: Immunohistochemical localization of the carboxy terminus of the novel mu opioid receptor splice variant MOR-IC within the human spinal cord
Abstract: The present study examined the distribution in the human spinal cord of a unique carboxy terminus sequence contained within MOR-IC, one of the recently described splice variants of the cloned mu opioid receptor gene MOR- I. Although MOR-I-like immunoreactivity (LI) and delta opioid receptor-like immunoreactivity were observed only in the superficial laminae. MOR-IC-LI was abundant in the superficial laminae of the dorsal horn and around the central canal. In the substantia gelatinosa, MOR-IC-LI was found in small diameter axonal elements, the cytoplasm and the plasmalemma of small spinal neurons and dendrites in inner lamina II and in some fibers within Lissauer's tract. These studies imply the presence of MOR-IC in human spinal cord and its distribution suggests that it plays a role in the control of pain processing. (C) 2000 Lippincott Williams and Wilkins.
Keywords: immunohistochemistry; human tissue; middle aged; protein localization; animals; pain; carboxy terminal sequence; neurons; central nervous system; tissue distribution; spinal cord; peptide fragments; rat; rats; mu opiate receptor; receptors, opioid, mu; protein isoforms; receptors, opioid, delta; mu opioid receptor; variation (genetics); splice variant; dna, recombinant; humans; human; male; female; priority journal; article; dorsal horn; mor-ic; delta opioid receptor; mor-i
Journal Title: NeuroReport
Volume: 11
Issue: 9
ISSN: 0959-4965
Publisher: Lippincott Williams & Wilkins  
Date Published: 2000-06-26
Start Page: 1953
End Page: 1957
Language: English
PUBMED: 10884050
PROVIDER: scopus
DOI: 10.1097/00001756-200006260-00029
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-0034717682&partnerID=40&md5=0c1a1f09f2a4fb734612cbc920631007
Notes: Export Date: 18 November 2015 -- Source: Scopus
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MSK Authors
  1. Sakir H Gultekin
    22 Gultekin
  2. Catherine Abbadie
    15 Abbadie
  3. Gavril W Pasternak
    414 Pasternak
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