Combined-modality therapy of rectal cancer with oxaliplatin-based regimens Journal Article
| Author: | Minsky, B. D. |
| Article Title: | Combined-modality therapy of rectal cancer with oxaliplatin-based regimens |
| Abstract: | There are 2 conventional treatments for clinically resectable rectal cancer. First is surgery and, if the tumor is stage T3 and/or N1/2, this is followed by postoperative combined modality therapy. The second is preoperative combined modality therapy followed by surgery and postoperative combined modality therapy if the tumor is stage uT3/4 and/or node-positive. There are a number of new chemotherapeutic agents that have been developed for the treatment of patients with colorectal cancer. Phase I/II trials examining the use of these new chemotherapeutic agents in combination with pelvic radiation therapy, most commonly in the preoperative setting are in progress and suggest higher complete response rates. There is considerable interest in integrating oxaliplatin into preoperative combined modality therapy regimens for rectal cancer. Base on results from phase I/II trials, the recommended regimen for patients who receive oxalipatin-base combined modality therapy is continuous infusion 5-fluorouracil or capecitabine with pelvic radiation. |
| Keywords: | clinical trial; neutropenia; review; bevacizumab; fluorouracil; diarrhea; multimodality cancer therapy; skin toxicity; capecitabine; postoperative care; preoperative care; combined modality therapy; chemotherapy; cancer staging; pelvis; blood toxicity; antineoplastic combined chemotherapy protocols; clinical assessment; continuous infusion; cetuximab; irinotecan; drug fatality; randomized controlled trials; folinic acid; gefitinib; drug infusion; intermethod comparison; radiation therapy; preoperative treatment; oxaliplatin; rectal neoplasms; rectum cancer; organoplatinum compounds; preoperative therapy; tegafur; multimodality therapy; sphincter preservation; raltitrexed; levamisole; uft; preoperative radiotherapy; proctitis; new drug; humans; human |
| Journal Title: | Clinical Colorectal Cancer |
| Volume: | 4 |
| Issue: | Suppl. 1 |
| ISSN: | 1533-0028 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2004-06-01 |
| Start Page: | S29 |
| End Page: | S36 |
| Language: | English |
| PROVIDER: | scopus |
| PUBMED: | 15212703 |
| DOI: | 10.3816/CCC.2004.s.005 |
| DOI/URL: | |
| Notes: | Clin. Colorectal Cancer -- Cited By (since 1996):2 -- Export Date: 16 June 2014 -- CODEN: CCCLC C2 - 15212703 -- Source: Scopus |
