Adjuvant therapy of resectable rectal cancer Journal Article
| Author: | Minsky, B. D. |
| Article Title: | Adjuvant therapy of resectable rectal cancer |
| Abstract: | The two conventional treatments for clinically resectable rectal cancer are surgery followed by postoperative combined modality therapy and preoperative combined modality therapy followed by surgery and postoperative chemotherapy, Preoperative therapy (most commonly combined modality therapy) has gained acceptance as a standard adjuvant therapy. The potential advantages of the preoperative approach include decreased tumor seeding, less acute toxicity, increased radiosensitivity due to more oxygenated cells, and enhanced sphincter preservation. There are a number of new chemotherapeutic agents that have been developed for the treatment of patients with colorectal cancer. Phase I/II trials examining the use of new chemotherapeutic agents in combination with pelvic radiation therapy are in progress. © 2002 Elsevier Science Ltd. All rights reserved. |
| Keywords: | controlled study; clinical trial; review; postoperative period; fluorouracil; cancer combination chemotherapy; drug efficacy; multimodality cancer therapy; capecitabine; adjuvant therapy; cancer adjuvant therapy; cancer radiotherapy; postoperative care; preoperative care; chemotherapy, adjuvant; combined modality therapy; radiotherapy, adjuvant; antineoplastic agent; pelvis; colorectal cancer; controlled clinical trial; irinotecan; standard; randomized controlled trials; folinic acid; gefitinib; radiosensitivity; preoperative treatment; oxaliplatin; rectal neoplasms; rectum cancer; oxygenation; rectum surgery; acute disease; rectal cancer; anus sphincter; raltitrexed; uft; humans; human |
| Journal Title: | Cancer Treatment Reviews |
| Volume: | 28 |
| Issue: | 4 |
| ISSN: | 0305-7372 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2002-08-01 |
| Start Page: | 181 |
| End Page: | 188 |
| Language: | English |
| DOI: | 10.1016/s0305-7372(02)00037-3 |
| PUBMED: | 12363458 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 14 November 2014 -- Source: Scopus |
