Combined modality therapy of resectable rectal cancer: Current approaches Journal Article
| Author: | Minsky, B. D. |
| Article Title: | Combined modality therapy of resectable rectal cancer: Current approaches |
| Abstract: | There are two conventional treatments for clinically resectable rectal cancer. First is surgery and, if the tumor is in stage T3 or N1-2, this is followed by postoperative combined modality therapy. The second is preoperative combined modality therapy followed by surgery and postoperative combined modality therapy if the tumor is classified at ultrasound as uT3-4 or N+. A number of new chemotherapeutic agents have been developed for the treatment of patients with colorectal cancer. Ongoing phase I and II trials are examining the use of these new chemotherapeutic agents in combination with pelvic radiation therapy, most commonly in the preoperative setting; early results suggest that the complete response rates are higher. Based on results from phase I and II trials, the standard regimen for patients who receive combined modality therapy is continuous infusion 5-fluorouracil (5-FU) and pelvic radiation. Regimens using CPT-11 or oxaliplatin-based combined modality therapy plus either continuous infusion 5-FU or capecitibine are under active development. |
| Keywords: | treatment outcome; cancer surgery; survival rate; clinical trial; review; cancer recurrence; bevacizumab; fluorouracil; cancer combination chemotherapy; multimodality cancer therapy; antineoplastic agents; capecitabine; adjuvant therapy; cancer adjuvant therapy; cancer radiotherapy; postoperative care; combined modality therapy; cancer staging; nuclear magnetic resonance imaging; positron emission tomography; neoplasm staging; colorectal cancer; radiotherapy; continuous infusion; cetuximab; irinotecan; folinic acid; gefitinib; preoperative treatment; oxaliplatin; rectal neoplasms; rectum cancer; chemoradiation; rectal cancer; colectomy; anus sphincter; raltitrexed; levamisole; uft; humans; prognosis; human |
| Journal Title: | Techniques in Coloproctology |
| Volume: | 8 |
| Issue: | 2 |
| ISSN: | 1123-6337 |
| Publisher: | Springer |
| Date Published: | 2004-08-01 |
| Start Page: | 67 |
| End Page: | 76 |
| Language: | English |
| PROVIDER: | scopus |
| PUBMED: | 15309641 |
| DOI: | 10.1007/s10151-004-0059-3 |
| DOI/URL: | |
| Notes: | Tech. Coloproctol. -- Cited By (since 1996):7 -- Export Date: 16 June 2014 -- CODEN: TECOF C2 - 15309641 -- Source: Scopus |
