Current and future directions in adjuvant combined-modality therapy of rectal cancer Conference Paper
| Author: | Minsky, B. D. |
| Title: | Current and future directions in adjuvant combined-modality therapy of rectal cancer |
| Conference Title: | The University of Texas M. D. Anderson Cancer Center Investigators' Workshop and Consensus Conference on UFT |
| Abstract: | Standard adjuvant therapy for transmural (T3) and/or node-positive rectal cancer is pelvic radiation therapy plus fluorouracil (5-FU)-based chemotherapy. Randomized trials are in progress to help determine the ideal chemotherapeutic agents and their optimal routes of administration in this setting, as well as to compare the efficacy and functional results of the pre- and postoperative bolus 5-FU/leucovorin combined-modality therapy approaches. New phase I trials will determine the recommended doses of tegafur and uracil (UFT) with oral leucovorin plus pre- or postoperative radiation therapy. |
| Keywords: | cancer survival; controlled study; clinical trial; cancer recurrence; cisplatin; fluorouracil; diarrhea; nonhuman; conference paper; cancer adjuvant therapy; chemotherapy, adjuvant; radiotherapy, adjuvant; neurotoxicity; pelvis; bolus injection; controlled clinical trial; phase 2 clinical trial; leukopenia; mucosa inflammation; randomized controlled trial; antineoplastic combined chemotherapy protocols; continuous infusion; irinotecan; vincristine sulfate; randomized controlled trials; radiation dose fractionation; folinic acid; forecasting; phase 3 clinical trial; phase 1 clinical trial; drug combinations; mitomycin; oxaliplatin; rectal neoplasms; rectum cancer; leucovorin; intravenous drug administration; oral drug administration; tegafur; rectum abdominoperineal resection; raltitrexed; levamisole; uft; uracil; antidotes; semustine; humans; human; trimetrexate glucuronate |
| Journal Title | Oncology (Norwalk) |
| Volume: | 11 |
| Issue: | 9 Suppl. 10 |
| Conference Dates: | 1997 Jan 17-18 |
| Conference Location: | Houston, TX |
| ISBN: | 0890-9091 |
| Publisher: | C M P Medica LLC * The Oncology Group |
| Date Published: | 1997-09-01 |
| Start Page: | 61 |
| End Page: | 68 |
| Language: | English |
| PUBMED: | 9348572 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Conference Paper -- Export Date: 17 March 2017 -- Source: Scopus |
