Postoperative radiation therapy for rectal cancer combined with UFT/leucovorin Journal Article
| Authors: | Rosenthal, D. I.; Haller, D. G.; Saltz, L.; Semple, D.; Minsky, B. D. |
| Article Title: | Postoperative radiation therapy for rectal cancer combined with UFT/leucovorin |
| Abstract: | Postoperative combined-modality therapy with fluorouracil (5-FU) and radiation therapy is accepted practice for high-risk rectal cancer. Postoperative pelvic radiotherapy alone may improve pelvic control, but is not associated with an improvement in survival. Protracted infusional 5-FU has been associated with decreased tumor recurrence and improved survival when combined with postoperative adjuvant pelvic radiotherapy. The use of new drugs and alternative ways of administering 5-FU is desirable. UFT plus leucovorin is an oral 5-FU prodrug with efficacy equal to 5-FU plus leucovorin in metastatic colorectal cancer. A combination of postoperative adjuvant UFT plus leucovorin concurrent with radiation therapy should be feasible, and the design of an ongoing phase I trial is presented. |
| Keywords: | clinical trial; dose response; multimodality cancer therapy; adjuvant therapy; chemotherapy, adjuvant; combined modality therapy; radiotherapy, adjuvant; antineoplastic agent; antineoplastic combined chemotherapy protocols; dose-response relationship, drug; drug combination; drug therapy, combination; folinic acid; adjuvant chemotherapy; phase 1 clinical trial; administration, oral; rectal neoplasms; rectum tumor; leucovorin; oral drug administration; tegafur; uracil; humans; human; article; 1 uft protocol; 1-uft protocol |
| Journal Title: | Oncology (Norwalk) |
| Volume: | 14 |
| Issue: | 10 Suppl. 9 |
| ISSN: | 0890-9091 |
| Publisher: | C M P Medica LLC * The Oncology Group |
| Date Published: | 2000-10-01 |
| Start Page: | 59 |
| End Page: | 62 |
| Language: | English |
| PUBMED: | 11098496 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 18 November 2015 -- Source: Scopus |
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