TGF-β: Guardian of T cell function Journal Article
| Authors: | Oh, S. A.; Li, M. O. |
| Article Title: | TGF-β: Guardian of T cell function |
| Abstract: | A fundamental aspect of the adaptive immune system is the generation and maintenance of a diverse and selftolerant T cell repertoire. Through its regulation of T cell development, homeostasis, tolerance, and differentiation, the highly evolutionarily conserved cytokine TGF-βcritically supports a functional T cell pool. The pleiotropic nature of this regulation is likely due to the elaborate control of TGF-βproduction and activation in the immune system, and the intricacy of TGF-β signaling pathways. In this review we discuss the current understanding of TGF-βregulation of T cells. Copyright © 2013 by The American Association of Immunologists, Inc. |
| Journal Title: | Journal of Immunology |
| Volume: | 191 |
| Issue: | 8 |
| ISSN: | 0022-1767 |
| Publisher: | The American Association of Immunologists, Inc |
| Date Published: | 2013-10-15 |
| Start Page: | 3973 |
| End Page: | 3979 |
| Language: | English |
| DOI: | 10.4049/jimmunol.1301843 |
| PROVIDER: | scopus |
| PUBMED: | 24098055 |
| PMCID: | PMC3856438 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 1 November 2013" - "CODEN: JOIMA" - "Source: Scopus" |
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