Development of promyelocytic zinc finger and ThPOK-expressing innate γδ T cells is controlled by strength of TCR signaling and Id3 Journal Article

   

Authors:	Alonzo, E. S.; Gottschalk, R. A.; Das, J.; Egawa, T.; Hobbs, R. M.; Pandolfi, P. P.; Pereira, P.; Nichols, K. E.; Koretzky, G. A.; Jordan, M. S.; Sant'angelo, D. B.
Article Title:	Development of promyelocytic zinc finger and ThPOK-expressing innate γδ T cells is controlled by strength of TCR signaling and Id3
Abstract:	The broad-complex tramtrack and bric a brac-zinc finger transcriptional regulator(BTB-ZF), promyelocytic leukemia zinc finger (PLZF), was recently shown to control the development of the characteristic innate T cell phenotype and effector functions of NK T cells. Interestingly, the ectopic expression of PLZF was shown to push conventional T cells into an activated state that seems to be proinflammatory. The factors that control the normal expression of PLZF in lymphocytes are unknown. In this study, we show that PLZF expression is not restricted to NK T cells but is also expressed by a subset of γδ T cells, functionally defining distinct subsets of this innate T cell population. A second BTB-ZF gene, ThPOK, is important for the phenotype of the PLZF-expressing γδ T cells. Most importantly, TCR signal strength and expression of inhibitor of differentiation gene 3 control the frequency of PLZF-expressing γδ T cells. This study defines the factors that control the propensity of the immune system to produce potentially disease-causing T cell subsets. Copyright © 2010 by The American Association of Immunologists, Inc.
Keywords:	signal transduction; controlled study; protein expression; unclassified drug; genetics; nonhuman; t lymphocyte; mouse; phenotype; animal; cytology; metabolism; mouse mutant; animals; mice; mice, knockout; gene; immune system; animal experiment; protein; transcription factor; cell differentiation; in vitro study; cell population; mice, inbred c57bl; physiology; cell lineage; c57bl mouse; transcription factors; t lymphocyte receptor; biosynthesis; immunology; kruppel like factor; kruppel-like transcription factors; innate immunity; immunity, innate; immunophenotyping; t-lymphocyte subsets; zinc finger protein; myeloid progenitor cell; myeloid progenitor cells; t lymphocyte subpopulation; t lymphocyte activation; lymphocyte antigen receptor; lymphocyte count; natural killer t cell; inhibitor of differentiation 3; promyelocytic leukemia zinc finger; thpok protein; idb3 protein, mouse; inhibitor of differentiation protein; th pok protein, mouse; th-pok protein, mouse; zbtb16 protein, mouse; gamma delta t cell; inhibitor of differentiation proteins; receptors, antigen, t-cell, gamma-delta; zinc fingers
Journal Title:	Journal of Immunology
Volume:	184
Issue:	3
ISSN:	0022-1767
Publisher:	The American Association of Immunologists, Inc
Date Published:	2010-02-01
Start Page:	1268
End Page:	1279
Language:	English
DOI:	10.4049/jimmunol.0903218
PUBMED:	20038637
PROVIDER:	scopus
PMCID:	PMC3991695
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-77949312475&partnerID=40&md5=457dcfbf9e24282f560ba41534635f51
Notes:	--- - "Cited By (since 1996): 15" - "Export Date: 20 April 2011" - "CODEN: JOIMA" - "Source: Scopus"

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