Requirements for eomesodermin and promyelocytic leukemia zinc finger in the development of innate-like CD8+ T cells Journal Article
| Authors: | Gordon, S. M.; Carty, S. A.; Kim, J. S.; Zou, T.; Smith-Garvin, J.; Alonzo, E. S.; Haimm, E.; Sant'angelo, D. B.; Koretzky, G. A.; Reiner, S. L.; Jordan, M. S. |
| Article Title: | Requirements for eomesodermin and promyelocytic leukemia zinc finger in the development of innate-like CD8+ T cells |
| Abstract: | Conventional and nonconventional T cell development occur in the thymus. Nonconventional thymocytes that bear characteristics typically associated with innate immune cells are termed innate-like lymphocytes (ILLs). Mice harboring a tyrosine to phenylalanine mutation in the adaptor protein Src homology 2 domain-containing leukocyte protein of 76 kDa at residue 145 (Y145F mice) develop an expanded population of CD8+CD122+CD44 + ILLs, typified by expression of the T-box transcription factor eomesodermin. Y145F mice also have an expanded population of γδ T cells that produce copious amounts of IL-4 via a mechanism that is dependent on the BTB-ZF transcription factor promyelocytic leukemia zinc finger. Using mice with T cell-specific deletion of Eomes, we demonstrate that this transcription factor is required for CD8+ ILL development in Y145F as well as wild-type mice. Moreover, we show that promyelocytic leukemia zinc finger and IL-4 are also required for the generation of this ILL population. Taken together, these data shed light on the cell-intrinsic and cell-extrinsic factors that drive CD8+ ILL differentiation. Copyright © 2011 by The American Association of Immunologists, Inc. |
| Keywords: | controlled study; protein expression; unclassified drug; nonhuman; cd8+ t lymphocyte; animal cell; mouse; phenotype; cell maturation; interleukin 4; animal experiment; cell fate; tyrosine; lymphocyte differentiation; gamma interferon; cytokine production; innate immunity; thymocyte; lymphocyte count; phenylalanine; promyelocytic leukemia protein; adaptor protein; promyelocytic leukemia zinc finger protein; lymphocyte subpopulation; chemokine receptor cxcr3; eomesodermin; src homology 2 domain containing leukocyte protein 76 |
| Journal Title: | Journal of Immunology |
| Volume: | 186 |
| Issue: | 8 |
| ISSN: | 0022-1767 |
| Publisher: | The American Association of Immunologists, Inc |
| Date Published: | 2011-04-15 |
| Start Page: | 4573 |
| End Page: | 4578 |
| Language: | English |
| DOI: | 10.4049/jimmunol.1100037 |
| PROVIDER: | scopus |
| PUBMED: | 21383242 |
| PMCID: | PMC3085897 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 23 June 2011" - "CODEN: JOIMA" - "Source: Scopus" |
