Development of PLZF-expressing innate T cells Journal Article
| Authors: | Alonzo, E. S.; Sant'angelo, D. B. |
| Article Title: | Development of PLZF-expressing innate T cells |
| Abstract: | Recent studies have shown that the transcriptional regulator promyelocytic leukemia zinc finger (PLZF) controls the development of essentially all of the innate-like features of invariant Natural Killer T (NKT) cells. For example, PLZF-deficient NKT cells do not acquire an 'activated' phenotype nor do they acquire the capacity to secrete multiple cytokines upon primary stimulation. The function of a subset of γδ T cells has now also been shown to be dependent upon expression of PLZF. Furthermore, IL-4 produced by PLZF-expressing cells causes some CD8 T cells to acquire innate-like features. Therefore, it is becoming clear that PLZF has a broad impact on the immune response. Here we discuss the current understanding of how expression of PLZF, the innate T cell determinant, is initiated during T cell development. © 2011 Elsevier Ltd. |
| Keywords: | signal transduction; protein expression; unclassified drug; review; nonhuman; protein domain; cd8+ t lymphocyte; t lymphocyte; phenotype; cell maturation; transcription factor; b lymphocyte; cell lineage; lymphocyte differentiation; t lymphocyte receptor; transcription regulation; thymus; cd4+ t lymphocyte; transgene; cell interaction; thymocyte; t lymphocyte activation; lymphocyte function; natural killer t cell; promyelocytic leukemia zinc finger |
| Journal Title: | Current Opinion in Immunology |
| Volume: | 23 |
| Issue: | 2 |
| ISSN: | 0952-7915 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2011-04-01 |
| Start Page: | 220 |
| End Page: | 227 |
| Language: | English |
| DOI: | 10.1016/j.coi.2010.12.016 |
| PROVIDER: | scopus |
| PMCID: | PMC3073746 |
| PUBMED: | 21257299 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 23 June 2011" - "CODEN: COPIE" - "Source: Scopus" |
