Development of PLZF-expressing innate T cells Journal Article


Authors: Alonzo, E. S.; Sant'angelo, D. B.
Article Title: Development of PLZF-expressing innate T cells
Abstract: Recent studies have shown that the transcriptional regulator promyelocytic leukemia zinc finger (PLZF) controls the development of essentially all of the innate-like features of invariant Natural Killer T (NKT) cells. For example, PLZF-deficient NKT cells do not acquire an 'activated' phenotype nor do they acquire the capacity to secrete multiple cytokines upon primary stimulation. The function of a subset of γδ T cells has now also been shown to be dependent upon expression of PLZF. Furthermore, IL-4 produced by PLZF-expressing cells causes some CD8 T cells to acquire innate-like features. Therefore, it is becoming clear that PLZF has a broad impact on the immune response. Here we discuss the current understanding of how expression of PLZF, the innate T cell determinant, is initiated during T cell development. © 2011 Elsevier Ltd.
Keywords: signal transduction; protein expression; unclassified drug; review; nonhuman; protein domain; cd8+ t lymphocyte; t lymphocyte; phenotype; cell maturation; transcription factor; b lymphocyte; cell lineage; lymphocyte differentiation; t lymphocyte receptor; transcription regulation; thymus; cd4+ t lymphocyte; transgene; cell interaction; thymocyte; t lymphocyte activation; lymphocyte function; natural killer t cell; promyelocytic leukemia zinc finger
Journal Title: Current Opinion in Immunology
Volume: 23
Issue: 2
ISSN: 0952-7915
Publisher: Elsevier Inc.  
Date Published: 2011-04-01
Start Page: 220
End Page: 227
Language: English
DOI: 10.1016/j.coi.2010.12.016
PROVIDER: scopus
PMCID: PMC3073746
PUBMED: 21257299
DOI/URL:
Notes: --- - "Export Date: 23 June 2011" - "CODEN: COPIE" - "Source: Scopus"
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  1. Eric Alonzo
    7 Alonzo