Altered development of NKT cells, γδ T cells, CD8 T cells and NK cells in a PLZF deficient patient Journal Article
| Authors: | Eidson, M.; Wahlstrom, J.; Beaulieu, A. M.; Zaidi, B.; Carsons, S. E.; Crow, P. K.; Yuan, J.; Wolchok, J. D.; Horsthemke, B.; Wieczorek, D.; Sant'angelo, D. B. |
| Article Title: | Altered development of NKT cells, γδ T cells, CD8 T cells and NK cells in a PLZF deficient patient |
| Abstract: | In mice, the transcription factor, PLZF, controls the development of effector functions in invariant NKT cells and a subset of NKT cell-like, γδ T cells. Here, we show that in human lymphocytes, in addition to invariant NKT cells, PLZF was also expressed in a large percentage of CD8+ and CD4+ T cells. Furthermore, PLZF was also found to be expressed in all γδ T cells and in all NK cells. Importantly, we show that in a donor lacking functional PLZF, all of these various lymphocyte populations were altered. Therefore, in contrast to mice, PLZF appears to control the development and/or function of a wide variety of human lymphocytes that represent more than 10% of the total PBMCs. Interestingly, the PLZF-expressing CD8+ T cell population was found to be expanded in the peripheral blood of patients with metastatic melanoma but was greatly diminished in patients with autoimmune disease. © 2011 Eidson et al. |
| Keywords: | controlled study; protein expression; unclassified drug; human cell; nonhuman; protein function; antigen expression; cd8+ t lymphocyte; animal cell; mouse; mus; melanoma; cell maturation; protein depletion; transcription factor; cd4+ t lymphocyte; growth regulation; natural killer cell; metastasis potential; autoimmune disease; cell expansion; t lymphocyte subpopulation; peripheral blood mononuclear cell; natural killer t cell; transcription factor plzf; gamma delta t lymphocyte |
| Journal Title: | PLoS ONE |
| Volume: | 6 |
| Issue: | 9 |
| ISSN: | 1932-6203 |
| Publisher: | Public Library of Science |
| Date Published: | 2011-01-01 |
| Start Page: | e24441 |
| Language: | English |
| DOI: | 10.1371/journal.pone.0024441 |
| PROVIDER: | scopus |
| PMCID: | PMC3167854 |
| PUBMED: | 21915328 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 3 October 2011" - "Source: Scopus" |
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