The BTB-zinc finger transcriptional regulator PLZF controls the development of invariant natural killer T cell effector functions Journal Article
| Authors: | Kovalovsky, D.; Uche, O. U.; Elhadad, S.; Hobbs, R. M.; Yi, W.; Alonzo, E.; Chua, K.; Eidson, M.; Kim, H. J.; Im, J. S.; Pandolfi, P. P.; Sant'angelo, D. B. |
| Article Title: | The BTB-zinc finger transcriptional regulator PLZF controls the development of invariant natural killer T cell effector functions |
| Abstract: | Invariant natural killer T cells (iNKT cells) have an innate immunity-like rapidity of response and the ability to modulate the effector functions of other cells. We show here that iNKT cells specifically expressed the BTB-zinc finger transcriptional regulator PLZF. In the absence of PLZF, iNKT cells developed, but they lacked many features of innate T cells. PLZF-deficient iNKT cells accumulated in lymph nodes rather than in the liver, did not express NK markers and did not have the characteristic activated phenotype. PLZF-deficient iNKT cells failed to secrete large amounts of interleukin 4 and interferon-γ after activation; however, some cells produced either interleukin 4 or interferon-γ but not both. PLZF, therefore, is an iNKT cell-specific transcription factor that is necessary for full functionality. |
| Keywords: | controlled study; protein expression; human cell; nonhuman; mouse; phenotype; animals; mice; animal tissue; cell maturation; interleukin 4; transcription factor; transcription, genetic; transcription factors; liver; lymphocyte activation; transcription regulation; gamma interferon; lymph node; kruppel-like transcription factors; cellular distribution; natural killer cell; killer cells, natural; innate immunity; cytokine release; interleukin-4; promyelocytic leukemia zinc finger protein |
| Journal Title: | Nature Immunology |
| Volume: | 9 |
| Issue: | 9 |
| ISSN: | 1529-2908 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2008-09-01 |
| Start Page: | 1055 |
| End Page: | 1064 |
| Language: | English |
| DOI: | 10.1038/ni.1641 |
| PUBMED: | 18660811 |
| PROVIDER: | scopus |
| PMCID: | PMC2662733 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 76" - "Export Date: 17 November 2011" - "CODEN: NIAMC" - "Source: Scopus" |
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