The BTB-ZF family of transcription factors: Key regulators of lineage commitment and effector function development in the immune system Journal Article

   

Authors:	Beaulieu, A. M.; Sant'angelo, D. B.
Article Title:	The BTB-ZF family of transcription factors: Key regulators of lineage commitment and effector function development in the immune system
Abstract:	Successful immunity depends upon the activity of multiple cell types. Commitment of pluripotent precursor cells to specific lineages, such as T or B cells, is obviously fundamental to this process. However, it is also becoming clear that continued differentiation and specialization of lymphoid cells is equally important for immune system integrity. Several members of the BTB-ZF family have emerged as critical factors that control development of specific lineages and also of specific effector subsets within these lineages. For example, BTB-ZF genes have been shown to control T cell versus B cell commitment and CD4 versus CD8 lineage commitment. Others, such as PLZF for NKT cells and Bcl-6 for T follicular helper cells, are necessary for the acquisition of effector functions. In this review, we summarize current findings concerning the BTB-ZF family members with a reported role in the immune system. Copyright © 2011 by The American Association of Immunologists, Inc.
Keywords:	signal transduction; protein expression; protein phosphorylation; unclassified drug; review; nonhuman; protein function; cd8+ t lymphocyte; protein analysis; phenotype; gene targeting; immune system; protein dna binding; transcription factor; cell fate; cell differentiation; b lymphocyte; cell lineage; gene expression regulation; protein processing; transcription regulation; cd4+ t lymphocyte; cytokine production; effector cell; protein bcl 6; pluripotent stem cell; protein family; lymphocytopoiesis; lymphocyte function; lymphoid cell; promyelocytic leukemia zinc finger protein; bcl 6 associated zinc finger protein; broad complex tramtrack bric a brac and zinc finger transcription factor; leukemia related factor; lymphoma related factor; myc associated zinc finger protein related factor; myc interacting zinc finger protein 1; th inducing poz kruppel life factor
Journal Title:	Journal of Immunology
Volume:	187
Issue:	6
ISSN:	0022-1767
Publisher:	The American Association of Immunologists, Inc
Date Published:	2011-09-15
Start Page:	2841
End Page:	2847
Language:	English
DOI:	10.4049/jimmunol.1004006
PROVIDER:	scopus
PMCID:	PMC3170133
PUBMED:	21900183
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-80053063773&partnerID=40&md5=a28484d6a32e4c688cd353ceb06ff33c
Notes:	--- - "Export Date: 2 November 2011" - "CODEN: JOIMA" - "Source: Scopus"

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